PMID: 1202939Dec 1, 1975Paper

Quantitative one-stage assays for factors V and X

American Journal of Clinical Pathology
A L Babson, M L Flanagan

Abstract

The relative sensitivities of the prothrombin time, Russell's viper venom time and activated partial thromboplastin time were determined in one-stage quantitative assays for factor V and factor X. Sensitivity was defined as the slope of the reference curve. The prothrombin time was the most sensitive test for factor X and the least sensitive for factor V. The Russell's viper venom time was the most sensitive test for factor V and least sensitive for factor X. The activated partial thromboplastin time approximated the sensitivity of Russell's viper venom for factor V and had intermediate sensitivity for factor X. The data indicate that factor V is best quantitated by the Russell's viper venom time and factor X by the prothrombin time, exactly the opposite of what is customarily done.

Citations

Mar 1, 1993·The Journal of Bone and Joint Surgery. American Volume·F T BlevinsJ Hall
Apr 17, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·W L ChandlerB D Spiess
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R D McBaneW G Owen
Jan 1, 1989·Veterinary Clinical Pathology·S L O'Neill, B F Feldman
Aug 13, 2021·Seminars in Thrombosis and Hemostasis·Gary William Moore

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