Quantitative outcome measures for systemic sclerosis-related Microangiopathy - Reliability of image acquisition in Nailfold Capillaroscopy

Microvascular Research
Graham DinsdaleAriane L Herrick

Abstract

Nailfold capillaroscopic parameters hold increasing promise as outcome measures for clinical trials in systemic sclerosis (SSc). Their inclusion as outcomes would often naturally require capillaroscopy images to be captured at several time points during any one study. Our objective was to assess repeatability of image acquisition (which has been little studied), as well as of measurement. 41 patients (26 with SSc, 15 with primary Raynaud's phenomenon) and 10 healthy controls returned for repeat high-magnification (300×) videocapillaroscopy mosaic imaging of 10 digits one week after initial imaging (as part of a larger study of reliability). Images were assessed in a random order by an expert blinded observer and 4 outcome measures extracted: (1) overall image grade and then (where possible) distal vessel locations were marked, allowing (2) vessel density (across the whole nailfold) to be calculated (3) apex width measurement and (4) giant vessel count. Intra-rater, intra-visit and intra-rater inter-visit (baseline vs. 1week) reliability were examined in 475 and 392 images respectively. A linear, mixed-effects model was used to estimate variance components, from which intra-class correlation coefficients (ICCs) were determined. ...Continue Reading

References

Jan 2, 2008·Seminars in Arthritis and Rheumatism·Francesca IngegnoliFlavio Fantini
Jun 5, 2013·Best Practice & Research. Clinical Rheumatology·Maurizio CutoloVanessa Smith
Sep 25, 2015·Clinical Rheumatology·Rebecca OverburyTracy M Frech

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Citations

Feb 2, 2019·Physics in Medicine and Biology·Anthony J Deegan, Ruikang K Wang
Jul 7, 2019·Clinical Rheumatology·Abdolamir KarbalaieBjörn-Erik Erlandsson
May 1, 2020·British Journal of Haematology·Raffaella Colombatti, Biree Andemariam
Aug 10, 2019·Clinical Rheumatology·Maurizio CutoloVanessa Smith
Jan 26, 2021·Rheumatology·Ariane L HerrickChris J Taylor

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