Quantitative parameters of seminiferous epithelium in secretory and excretory oligoazoospermia

Archives of Andrology
Sandro FrancavillaG Cordeschi

Abstract

Testicular biopsy specimens from infertile men (sperm count, less than 10(6)/ml) were evaluated on 1-micron thick sections, and counts of stem cells and differentiated spermatogonia, primary spermatocytes, early and late spermatids, and Sertoli cells were compared to counts in six fertile men. Biopsy specimens were also compared for the appearance of seminiferous tubule wall, blood vessels, and interstitium. Infertile men were grouped according to the following diagnoses: hypospermatogenesis (n = 5), spermatocyte arrest of spermatogenesis (n = 5), and obstruction of the genital tract (n = 7). A low productivity of spermatogenesis in cases of hypospermatogenesis appeared to be due to an exaggerated degeneration of primary spermatocytes and to a yield of abnormal spermatids. A block of meiosis in spermatocyte arrest was associated with a degeneration of primary spermatocytes and with a reduced number of staminal spermatogonia. Abnormal spermiogenesis was observed in cases of obstruction of the genital tract and was associated with an increase in stem cell spermatogonia. A thickening of seminiferous tubule and blood vessel walls could be responsible for the limited functional capacity of Sertoli cells, causing altered spermiogenes...Continue Reading

References

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Citations

Sep 5, 2003·Journal of Andrology·Manuel NistalRicardo Paniagua
Dec 22, 2004·BJU International·Tomomoto IshikawaMasato Fujisawa
Nov 1, 1992·Differentiation; Research in Biological Diversity·D EscalierJ Schrével

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