Quantitative performance of 124 I PET/MR of neck lesions in thyroid cancer patients using 124 I PET/CT as reference

EJNMMI Physics
Walter JentzenJames Nagarajah

Abstract

In patients with differentiated thyroid cancer (DTC), serial 124I PET/CT imaging is, for instance, used to assess the absorbed (radiation) dose to lesions. Frequently, the lesions are located in the neck and they are close to or surrounded by different tissue types. In contrast to PET/CT, MR-based attenuation correction in PET/MR may be therefore challenging in the neck region. The aim of this retrospective study was to assess the quantitative performance of 124I PET/MRI of neck lesions by comparing the MR-based and CT-based 124I activity concentrations (ACs). Sixteen DTC patients underwent PET/CT scans at 24 and 120 h after administration of about 25 MBq 124I. Approximately 1 h before or after PET/CT examination, each patient additionally received a 24-h PET/MR scan and sometimes a 120-h PET/MR scan. PET images were reconstructed using the respective attenuation correction approach. Appropriate reconstruction parameters and corrections were used to harmonize the reconstructed PET images to provide, for instance, similar spatial resolution. For each lesion, two types of ACs were ascertained: the maximum AC (max-AC) and an average AC (avg-AC). The avg-AC is the average activity concentration obtained within a spherical volume of...Continue Reading

References

May 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Walter JentzenAndreas Bockisch
Nov 28, 2012·Seminars in Nuclear Medicine·Ilja BezrukovBernd J Pichler
Feb 7, 2013·Magma·Thomas Beyer, Ewald Moser
Oct 22, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Walter JentzenSandra Rosenbaum-Krumme
Mar 26, 2015·Abdominal Imaging·Tyler J FraumBarry A Siegel
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Feb 27, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Roel WiertsWalter Jentzen
May 21, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Walter JentzenIna Binse

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Citations

Jul 13, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Manuel WeberWalter Jentzen

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