Quantitative PET measurements of regional myocardial blood flow: observations in humans with ischemic heart disease

Cardiology
H GewirtzAlan J Fischman

Abstract

This review focuses on several related issues concerning positron emission tomography measurements of regional myocardial blood flow using 13-N-ammonia in humans. The effect of partial volume correction on estimates of K1, the model parameter describing myocardial blood flow, is considered. In addition a new method for computing K1 images of myocardial flow distribution is briefly described and compared to a standard method. Potential differences between K1 and equilibrium levels of 13-N-ammonia in the myocardium for estimation of myocardial blood flow are discussed also. The issue of heterogeneity of myocardial blood flow and flow reserve in normal volunteers is considered from the clinical point of view in terms of evaluation of patients with ischemic heart disease. Finally, the use of absolute measurement of adenosine-stimulated myocardial blood flow to assess physiological significance of coronary artery stenoses is addressed.

Citations

Sep 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Peter WieleppWolfgang Burchert
Jul 10, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Mireille LortieRobert A DeKemp
Oct 15, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Arun AbrahamBenjamin J W Chow
Apr 14, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ran KleinRobert A deKemp
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Dec 29, 2000·Journal of the American College of Cardiology·A TawakolH Gewirtz
Oct 2, 2002·Journal of the American College of Cardiology·Ahmed TawakolHenry Gewirtz
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Nov 12, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Henry Gewirtz
Aug 24, 2020·JACC. Cardiovascular Imaging·Vasken DilsizianCharles A Herzog

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