Quantitative Pharmaco-Electroencephalography in Antiepileptic Drug Research.

CNS Drugs
Yvonne HöllerKlaus Lehnertz

Abstract

Pharmaco-electroencephalography (pharmaco-EEG) has never gained great popularity in epilepsy research. Nevertheless, the electroencephalogram (EEG) is the most important neurological examination technique in this patient population. Development and investigation of antiepileptic drugs (AEDs) involves EEG for diagnosis and outcome evaluation. In contrast to the common use of the EEG for documenting the effect of AEDs on the presence of interictal epileptiform activities or seizures, quantitative analysis of drug responses in the EEG are not yet standard in pharmacological studies. We provide an overview of dedicated pharmaco-EEG studies with AEDs in humans. A systematic search in PubMed yielded 43 articles, which were reviewed for their relevance. After excluding studies according to our exclusion criteria, nine studies remained. These studies plus the retrieved references from the bibliographies of the identified studies yielded 37 studies to be included in the review. The most prominent method in pharmaco-EEG research for AEDs was analysis of the frequency content in response to drug intake, often with quantitative methods such as spectral analysis. Despite documenting the effect of the drug on brain activity, some studies wer...Continue Reading

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Citations

Aug 6, 2019·Frontiers in Neurology·Pieter van MierloSerge Vulliemoz
Dec 29, 2020·Clinical EEG and Neuroscience·Lukasz M KonopkaRonald Wuest
Nov 29, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lorenzo RicciMario Tombini
Jul 11, 2021·Autonomic Neuroscience : Basic & Clinical·Randi von Wrede, Rainer Surges
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jacopo LanzoneGiovanni Assenza

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