Quantitative profiles of the mRNAs of ER-alpha and its novel variant ER-alpha36 in breast cancers and matched normal tissues.

Journal of Zhejiang University. Science. B
Yi ZhengLi-song Teng

Abstract

The novel estrogen receptor-alpha (ER-alpha) variant ER-alpha36 is reported to be functional in the estrogen signaling pathway and is related to tamoxifen resistance in breast cancer. However, ER-alpha36 tends to be a favorable factor for survival in patients without tamoxifen therapy. To investigate the mechanisms behind this paradox, we determined the differences between the transcriptional profiles of ER-alpha36 and full-length ER-alpha (ER-alpha66) in breast cancers and matched normal tissues. We analyzed ER-alpha36 and ER-alpha66 messenger RNA (mRNA) levels in 74 pairs of breast cancers and matched normal tissues using a real-time quantitative polymerase chain reaction (PCR) assay, and correlated the results with their clinicopathological characteristics. Breast cancers expressed lower ER-alpha36 mRNA levels than matched normal tissues regardless of their ER-alpha66 expression status. Down-regulation of ER-alpha36 mRNA was correlated with local progression, lymph node metastasis, and advanced cancer stage. The level of ER-alpha66 mRNA was lower in ER-alpha negative breast cancers compared with matched normal tissues. No differences in ER-alpha66 mRNA levels were observed during cancer progression. Down-regulation of ER-alp...Continue Reading

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Citations

Jan 23, 2014·Journal of Translational Medicine·Yu GuLisong Teng
Feb 11, 2015·Pathology, Research and Practice·Norbert Nass, Thomas Kalinski
Nov 3, 2015·European Journal of Cell Biology·Kamil Sołtysik, Piotr Czekaj
May 11, 2016·Molecular and Cellular Endocrinology·Emily K PugachLeslie A Leinwand
Jun 13, 2020·International Journal of Molecular Sciences·Charlène ThiebautHélène Dumond
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh MahboobifardMohammad H Pourgholami
Jul 25, 2021·International Journal of Molecular Sciences·George NotasElias Castanas

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