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Quantitative Proteome Analysis of Atg5 -Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome

MSystems

Nov 5, 2019

Kiran Bala SharmaManjula Kalia

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Abstract

Basal autophagy is crucial for maintenance of cellular homeostasis. ATG5 is an essential protein for autophagosome formation, and its depletion has been extensively used as a tool to disrupt autophagy. Here, we characterize the impact of Atg5 deficiency on the cellular proteome of mouse...read more

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Tissue Adhesions
Autophagy
Cell Adhesion
Cell Differentiation Process
Down-Regulation
Gene Expression
Genes
Interferons
Interleukin-6
Lipopolysaccharides
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Quantitative Proteome Analysis of Atg5 -Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome

MSystems

Nov 5, 2019

Kiran Bala SharmaManjula Kalia

PMID: 31690592

DOI: 10.1128/msystems.00481-19

Abstract

Basal autophagy is crucial for maintenance of cellular homeostasis. ATG5 is an essential protein for autophagosome formation, and its depletion has been extensively used as a tool to disrupt autophagy. Here, we characterize the impact of Atg5 deficiency on the cellular proteome of mouse...read more

Mentioned in this Paper

Tissue Adhesions
Autophagy
Cell Adhesion
Cell Differentiation Process
Down-Regulation

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