Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect

Artificial Cells, Nanomedicine, and Biotechnology
Minzhi ZhaoZhiyuan Hu

Abstract

The first nano-platform commercialized as a drug delivery system was a liposomal formulation. The application of liposome technology resolved the issues of paclitaxel (PTX) insolubility and eliminated the use of solvents causing toxic side-effects, which enabled to apply higher drug doses leading to an enhanced drug efficacy. The growth-inhibitory activity of liposome-encapsulated PTX was retained in vitro against a variety of tumor cell. To investigate the drug efficacy in the system biological level, quantitative proteomic analysis was employed to study the molecular mechanism of the anti-tumor effect of Lipusu® (lip) compared with PTX on lung cancer cell A549. The functions of the differential expressed proteins were correlated to the negative effect to cell proliferation due to regulation of hippo pathway and prolonged cell cycle, as well as inhibitory cell exocytosis, which would cause the aggregation of free PTX. This investigation focused on the direct biological effect of lip to cancer cells. It was different from pharmaceutical issues about drug exposure, delivery and distribution which were widely investigated in other traditional studies. It was the first study about the drug effect of lip from the global molecular b...Continue Reading

References

Apr 1, 1990·Journal of Microencapsulation·M H BartoliF Puisieux
Jan 1, 1985·Annals of the New York Academy of Sciences·P Geck, B Pfeiffer
Jun 1, 1994·Pharmaceutical Research·A Sharma, R M Straubinger
Dec 1, 1995·Journal of Pharmaceutical Sciences·A SharmaR J Bernacki
Oct 22, 1996·Cancer Letters·A SharmaR M Straubinger
Jun 8, 2001·Investigational New Drugs·L van ZuylenA Sparreboom
Aug 31, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H GelderblomA Sparreboom
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
May 25, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lynn M IwamotoRandal K Wada
Sep 6, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Quincy ChuUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
Nov 21, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qian ZhangLi-Li Gao
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Haijiang CaiRobert H Chow
Mar 9, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Xianhuo WangLijuan Chen
May 5, 2010·Genes & Development·Bin ZhaoKun-Liang Guan
Apr 3, 2012·Carcinogenesis·Zhongyi HuHuiqing Yuan
Sep 20, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Stěpán Koudelka, Jaroslav Turánek
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Aug 6, 2013·Cancer Biomarkers : Section a of Disease Markers·Hiroaki KomatsuHideki Wanibuchi
Nov 2, 2015·Journal of Prosthodontic Research·Shariq NajeebFahad Siddiqui
May 16, 2017·International Journal of Pharmaceutics·Ezequiel BernabeuDiego A Chiappetta

❮ Previous
Next ❯

Citations

Oct 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan ŠkubníkSilvie Rimpelová

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Manuela BanciuGert Storm
International Journal of Clinical and Experimental Medicine
Yunjie CaoXiaozhou He
© 2022 Meta ULC. All rights reserved