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Quantitative Proteomic and Network Analysis of Differentially Expressed Proteins in PBMC of Friedreich's Ataxia (FRDA) Patients

Frontiers in Neuroscience

Oct 14, 2019

Deepti PathakMoganty Raja Rajeswari

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Abstract

Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by an expanded (GAA) trinucleotide repeat in the FXN gene. The extended repeats expansion results in reduced transcription and, thereby, decreased expression of the mitochondrial protein, frataxin. Gi...read more

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Alpha-Actin
Biological Markers
Cell Growth
Clinical Trials
Down-Regulation
Friedreich Ataxia
Heart
Inflammation
Myocardium
Transcription, Genetic
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Quantitative Proteomic and Network Analysis of Differentially Expressed Proteins in PBMC of Friedreich's Ataxia (FRDA) Patients

Frontiers in Neuroscience

Oct 14, 2019

Deepti PathakMoganty Raja Rajeswari

PMID: 31680804

DOI: 10.3389/fnins.2019.01054

Abstract

Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by an expanded (GAA) trinucleotide repeat in the FXN gene. The extended repeats expansion results in reduced transcription and, thereby, decreased expression of the mitochondrial protein, frataxin. Gi...read more

Mentioned in this Paper

Alpha-Actin
Biological Markers
Cell Growth
Clinical Trials
Down-Regulation

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