Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic review

Frontiers in Microbiology
Chang-Ro LeeSang Hee Lee

Abstract

The increase of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) poses a worldwide and serious health threat. Although new antibiotics, such as daptomycin and linezolid, have been developed for the treatment of infections of Gram-positive pathogens, the emergence of daptomycin-resistant and linezolid-resistant strains during therapy has now increased clinical treatment failures. In the past few years, studies using quantitative proteomic methods have provided a considerable progress in understanding antibiotic resistance mechanisms. In this review, to understand the resistance mechanisms to four clinically important antibiotics (methicillin, vancomycin, linezolid, and daptomycin) used in the treatment of Gram-positive pathogens, we summarize recent advances in studies on resistance mechanisms using quantitative proteomic methods, and also examine proteins playing an important role in the bacterial mechanisms of resistance to the four antibiotics. Proteomic researches can identify proteins whose expression levels are changed in the resistance mechanism to only one antibiotic, such as LiaH in daptomycin resistance and PrsA in vancomycin resistance, and many proteins simultaneously inv...Continue Reading

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Citations

Mar 1, 2016·Frontiers in Microbiology·Youcef Soufi, Boumediene Soufi
Apr 12, 2016·Frontiers in Microbiology·Francisco J Pérez-Llarena, Germán Bou
Oct 27, 2016·Biochemical Pharmacology·Çiğdem Yılmaz, Gülay Özcengiz
Jan 1, 2017·Journal of Global Antimicrobial Resistance·Van Chi ThaiThi Thu Hoai Nguyen
Mar 30, 2017·Frontiers in Cellular and Infection Microbiology·Chang-Ro LeeSang Hee Lee
Jul 2, 2020·Infection and Drug Resistance·Ehsaneh KhodadadiHossein Samadi Kafil
May 5, 2020·BioImpacts : BI·Bhavya Somalapura GangadharappaGajanan Sathe
Aug 22, 2020·Journal of Proteomics·Ahmed KandilShymaa Enany

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Methods Mentioned

BETA
gene knockout

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