PMID: 2494246Apr 1, 1989Paper

Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial

Journal of the American College of Cardiology
F J WackersB L Zaret

Abstract

In Thrombolysis in Myocardial Infarction (TIMI) Phase I,290 patients with acute myocardial infarction were randomized to either intravenous recombinant tissue-type plasminogen activator (rt-PA) or intravenous streptokinase. Two hundred twenty-nine patients had radionuclide ventriculograms at discharge for assessment of global and regional left ventricular ejection fraction. Among these 229 patients 185 had totally occluded infarct-related arteries, and angiographic reperfusion of the infarct-related artery occurred in 69% of patients treated with rt-PA and 28% of patients treated with streptokinase (p less than 0.001). Mean global left ventricular ejection fraction was not different for rt-PA-treated patients compared with streptokinase-treated patients (0.46 versus 0.45). However, the average regional ejection fraction of the regions subtended by the infarct-related artery showed a trend toward better average infarct region ejection fraction in patients treated with rt-PA than in patients treated with streptokinase (0.40 versus 0.36; 0.05 less than p less than 0.06). Analysis of data according to perfusion status of the infarct-related artery showed no difference in mean global left ventricular ejection fraction between patien...Continue Reading

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References

Apr 1, 1986·Journal of the American College of Cardiology·M L SimoonsA van der Laarse
Apr 1, 1986·Journal of the American College of Cardiology·P W SerruysW J Remme
Sep 1, 1986·The American Journal of Cardiology·D G FineM S Gotsman
Jun 2, 1983·The New England Journal of Medicine·J L AndersonA D Hagan
Jul 20, 1983·The American Journal of Cardiology·J R CorbettJ T Willerson

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Citations

Mar 1, 1994·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·L W Gimple, G A Beller
Aug 1, 1995·International Journal of Cardiology·Y RozenmanD Gilon
May 10, 2005·The American Journal of Cardiology·Barry Lewis Zaret
Jun 10, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·George SaabRobert S B Beanlands
Apr 17, 2001·Cardiology in Review·P Kailasnath, A J Sinusas
Aug 1, 1993·The Annals of Thoracic Surgery·J A ElefteriadesG S Kopf
Dec 5, 1991·The American Journal of Cardiology·J P BassandJ E Wolf
Mar 9, 1995·Journal of Interventional Cardiology·C P CannonE M Antman

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