Quantitative relationship between coronary artery calcium and myocardial blood flow by hybrid rubidium-82 PET/CT imaging in patients with suspected coronary artery disease

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Roberta AssanteAlberto Cuocolo

Abstract

We assessed the relationship between coronary artery calcium (CAC) score, myocardial blood flow (MBF) and coronary flow reserve (CFR) in patients undergoing hybrid 82Rb positron emission tomography (PET)/computed tomography (CT) imaging for suspected CAD. We also evaluated if CAC score is able to predict a reduced CFR independently from conventional coronary risk factors. A total of 637 (mean age 58 ± 13 years) consecutive patients were studied. CAC score was measured according to the Agatston method and patients were categorized into 4 groups (0, 0.01-99.9, 100-399.9, and ≥400). Baseline and hyperemic MBF were automatically quantified. CFR was calculated as the ratio of hyperemic to baseline MBF and it was considered reduced when <2. Global CAC score showed a significant inverse correlation with hyperemic MBF and CFR (both P < .001), while no correlation between CAC score and baseline MBF was found. At multivariable logistic regression analysis age, diabetes and CAC score were independently associated with reduced CFR (all P < .001). The addition of CAC score to clinical data increased the global chi-square value for predicting reduced CFR from 81.01 to 91.13 (P < .01). Continuous net reclassification improvement, obtained by ...Continue Reading

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Citations

Feb 6, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alan RozanskiDaniel S Berman
Nov 3, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Carmela NappiAlberto Cuocolo
Mar 7, 2017·Revista española de medicina nuclear e imagen molecular·V GaudieriA Cuocolo
Aug 18, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Roberta AssanteAlberto Cuocolo
Oct 5, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alberto CuocoloMario Petretta
Feb 16, 2019·European Heart Journal Cardiovascular Imaging·Valeria GaudieriAlberto Cuocolo
Oct 19, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberta AssanteWanda Acampa
Jan 24, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Carmela NappiAlberto Cuocolo
Dec 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Emilia ZampellaAlberto Cuocolo
Jul 11, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Emilia ZampellaAlberto Cuocolo
Mar 21, 2017·Current Treatment Options in Cardiovascular Medicine·Sandeep S HedgireBrian B Ghoshhajra
Nov 10, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael A AlJaroudi, Fadi G Hage
May 10, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wanda AcampaAlberto Cuocolo
May 23, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Fanghu WangLijun Lu
Jun 21, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Carmela Nappi, Alberto Cuocolo
Dec 26, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberta GreenAlberto Cuocolo
Nov 3, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Roberto SciagràUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)
Feb 19, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberta AssanteWanda Acampa
Aug 25, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Adriana D'AntonioWanda Acampa

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