PMID: 6139889Jan 1, 1983

Quantitative relationship between structure and mutagenic activity in a series of 5-nitroimidazoles

Teratogenesis, Carcinogenesis, and Mutagenesis
G L BiagiP A Borea

Abstract

The mutagenic activity of 20 5-nitroimidazoles was tested in Salmonella typhimurium TA-100 strain by means of the Ames test. A multiple regression analysis using the interaction term MR2 X Hb and the chromatographic Rm values yielded the equation: (formula see text); where C is the molar concentration (1 M X 10(-6) of each drug increasing the revertants by five times in the Ames test. The interaction term MR2 X Hb takes into account the positive effect exerted by substituents characterized by higher molar refractivity (MR2) and capable of hydrogen bonding (Hb). It was found that when the electroreduction potentials (EIc.p.) were included, the correlation was not improved.

References

Apr 1, 1978·Journal of Medicinal Chemistry·Y W Chien, S S Mizuba
Oct 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·K G KemsleyG O Phillips
Nov 1, 1975·Journal of Pharmaceutical Sciences·D R SanvordekerH J Lambert
May 1, 1973·Journal of General Microbiology·D I EdwardsH Carne
Sep 1, 1970·Journal of Medicinal Chemistry·M W MillerA R English
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·G Cantelli-FortiG L Biagi
May 1, 1981·Mutation Research·C E Voogd
Aug 1, 1981·The Journal of Antimicrobial Chemotherapy·A V Reynolds

Citations

Jan 1, 1985·Molecular and Biochemical Parasitology·N YarlettM Müller
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L TurnerD Roberts
Mar 29, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·María Leticia Saucedo-MendiolaAlfredo Téllez-Valencia
Jan 1, 1986·Environmental Mutagenesis·M R FriersonH S Rosenkranz
Jan 1, 1986·Teratogenesis, Carcinogenesis, and Mutagenesis·P HreliaG Cantelli-Forti

Related Concepts

Clastogens
Nitroimidazoles
Salmonella typhimurium LT2
Structure-Activity Relationship
Physicochemical Phenomena

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