PMID: 2485909Nov 1, 1989Paper

Quantitative relationships between hydrophobicity and hypotensive activity of diazacycloalkane derivatives

Polish Journal of Pharmacology and Pharmacy
A NasalK Wisterowicz

Abstract

The effect of a series of ten newly synthesized diazacycloalkanes as well as four standard imidazoline drugs on blood pressure of anesthetized normotensive rats was measured. The hypotensive activity of the agents studied, expressed as logit of the maximum effect, logit E(%), was quantitatively related to the changes in their chemical structure. Highly significant relationship between the hydrophobicity parameter, sigma f, and logit E(%) value has been found.

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