PMID: 9426359Jan 14, 1998Paper

Quantitative responses of serum folate to increasing intakes of folic acid in healthy women

European Journal of Clinical Nutrition
A S Truswell, S Kounnavong

Abstract

Health authorities are advising people to increase folate intake and more foods are being fortified with folic acid. Estimation of dietary folate is difficult because nutrient data bases lack this nutrient in many countries and bioavailability is variable. To see if serum folate can be used to reflect effective folate intake, we have measured serum folate after healthy women had taken different doses of pure folic acid supplements in the nutritional range. A total of 20 volunteer subjects took part in one or more of three experiments, six of them took part in all three. In each experiment subjects took two different doses of folic acid, each for three weeks. Experiment (1) 100 micrograms then 1000 micrograms/d; experiment (2) 500 micrograms then 1500 micrograms/d; experiment (3) 1000 then 2000 micrograms/d. Serum folate was measured after overnight fast with a homogenous enzyme binding assay kit. In experiment (3) red cell folates were also measured. It took three weeks' of the same supplement for serum folate to reach its full higher value. Mean serum folates of small groups of subjects were significantly higher with each higher dose of supplement. The biggest increase was for the first 100 micrograms that is in the range of i...Continue Reading

Citations

Aug 25, 2001·The British Journal of Nutrition·H CrewsG Williamson
Aug 6, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Alida Melse-BoonstraClive West
Jan 5, 2002·Lancet·N J WaldD S Wald
Jul 16, 2005·Journal of Clinical Epidemiology·Siobhan HicklingJoseph Hung
Dec 1, 2001·Nutrition Research Reviews·I A BrouwerR P Steegers-Theunissen
Jul 17, 2018·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jessica BayesJanet Schloss
Mar 15, 2001·Epidemiology·L A TurnerV M Prabhakaran
Mar 2, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Christopher-John L FarrellMarkus Herrmann
May 2, 2018·BioMed Research International·Abel GedefawBirkneh Tilahun Tadesse

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