Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

Pain
C MaierD-R Treede

Abstract

Neuropathic pain is accompanied by both positive and negative sensory signs. To explore the spectrum of sensory abnormalities, 1236 patients with a clinical diagnosis of neuropathic pain were assessed by quantitative sensory testing (QST) following the protocol of DFNS (German Research Network on Neuropathic Pain), using both thermal and mechanical nociceptive as well as non-nociceptive stimuli. Data distributions showed a systematic shift to hyperalgesia for nociceptive, and to hypoesthesia for non-nociceptive parameters. Across all parameters, 92% of the patients presented at least one abnormality. Thermosensory or mechanical hypoesthesia (up to 41%) was more frequent than hypoalgesia (up to 18% for mechanical stimuli). Mechanical hyperalgesias occurred more often (blunt pressure: 36%, pinprick: 29%) than thermal hyperalgesias (cold: 19%, heat: 24%), dynamic mechanical allodynia (20%), paradoxical heat sensations (18%) or enhanced wind-up (13%). Hyperesthesia was less than 5%. Every single sensory abnormality occurred in each neurological syndrome, but with different frequencies: thermal and mechanical hyperalgesias were most frequent in complex regional pain syndrome and peripheral nerve injury, allodynia in postherpetic neu...Continue Reading

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References

Jan 1, 1992·Progress in Neurobiology·R D TreedeJ N Campbell
Jan 1, 1994·Somatosensory & Motor Research·A V ApkarianS J Bolanowski
Dec 16, 1998·Neurobiology of Disease·H L FieldsR Baron
Feb 5, 2002·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ron AmirMarshall Devor
Mar 13, 2002·European Journal of Pain : EJP·Per Hansson
Mar 7, 2003·Pain·Troels S Jensen, Ralf Baron
Apr 12, 2003·Brain : a Journal of Neurology·J LorenzK L Casey
Jun 25, 2003·European Journal of Pain : EJP·Jörgen Boivie
Sep 3, 2003·Cephalalgia : an International Journal of Headache·V J SinayA Dubrovsky
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·A D Craig, A Blomqvist
Feb 27, 2004·Brain : a Journal of Neurology·Gunnar WasnerRalf Baron
May 12, 2004·Neuroscience Letters·Walter Magerl, Rolf-Detlef Treede
May 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J Olesen, T J Steiner
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bryan C HainsStephen G Waxman
Jul 28, 2004·Pain·Peter Vestergaard RasmussenFlemming Winther Bach
Jun 24, 2005·Muscle & Nerve·José L OchoaHugh Bostock
Nov 18, 2005·European Journal of Pain : EJP·R RolkeR-D Treede
Jun 15, 2006·The Clinical Journal of Pain·R Norman Harden, Stephen P Bruehl
Aug 26, 2006·Nature Clinical Practice. Neurology·Ralf Baron
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristin ØrstavikH Erik Torebjörk
Jan 29, 2008·European Journal of Pain : EJP·Rolf-Detlef Treede, Ralf Baron
Nov 21, 2008·European Journal of Pain : EJP·Claudia Maria Santos AgostinhoChristoph Maier

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Citations

Jul 4, 2012·Journal of Neurology·Joseph A KittermanFrederick S Kaplan
Jul 5, 2012·Journal of Neurology·A TruiniG Cruccu
Aug 11, 2012·Journal of Neurology·Kathrin ArningRalf Baron
Mar 1, 2012·Der Schmerz·C Maier, R Baron
Dec 1, 2012·Journal of Pharmacokinetics and Pharmacodynamics·Ashraf YassenAlbert Dahan
Oct 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jacqueline BaileyCandida S McCabe
May 10, 2012·Current Diabetes Reports·Giuseppe Lauria, Raffaella Lombardi
May 25, 2012·Current Diabetes Reports·Elena K KrumovaChristoph Maier
Apr 27, 2012·Current Pain and Headache Reports·Doreen B PfauRolf-Detlef Treede
Oct 1, 2013·Lancet Neurology·Ian GilronAnthony H Dickenson
Apr 3, 2013·Nature Reviews. Rheumatology·Luda DiatchenkoWilliam Maixner
Jun 26, 2013·British Journal of Anaesthesia·L A Colvin, D J Rowbotham
Nov 29, 2011·Rheumatology·Vikki WyldePaul Dieppe
Apr 2, 2011·Regional Anesthesia and Pain Medicine·Henning HermannsInge Bauer
Jun 7, 2011·The Clinical Journal of Pain·Andrea WestermannChristoph Maier
Oct 6, 2012·European Neurology·Maija Haanpää, Rolf-Detlef Treede
Aug 7, 2012·BMC Musculoskeletal Disorders·Andreas GerhardtWolfgang Eich
Feb 16, 2013·Genome Medicine·Megan CrowStephen B McMahon
May 12, 2011·PloS One·Volker HugeShahnaz Christina Azad
Jul 14, 2012·Journal of Pain Research·Emanuel N van den BroekeOliver Hg Wilder-Smith
Mar 29, 2014·Current Opinion in Supportive and Palliative Care·Maren ReimerRalf Baron
Sep 1, 2012·Pain Management·Eva Widerström-Noga
Jun 14, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jiang-Ti KongSean Mackey
Jan 1, 2013·Pain Management·Maija Haanpää
Jan 30, 2014·Nature Neuroscience·Steven A PrescottYves De Koninck
Apr 2, 2014·Nature Reviews. Rheumatology·Matthew ThakurRalf Baron
Aug 22, 2014·Current Diabetes Reports·Giuseppe LauriaUNKNOWN PROPANE Study group
Jun 17, 2014·International Journal of Oral and Maxillofacial Surgery·S F KothariP Svensson
Aug 20, 2014·Nature Reviews. Neurology·Janne GierthmühlenRalf Baron

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