Quantitative sensory testing in vulvodynia patients and increased peripheral pressure pain sensitivity

Obstetrics and Gynecology
Jutta GieseckeRichard H Gracely

Abstract

To assess both regional (vulvar) and overall (generalized) pain sensitivity in women with vulvodynia to determine whether both are increased, suggestive of altered central pain processing. Seventeen patients (aged 18-60 years) with vulvodynia and 23 age-matched control subjects were included in this cross-sectional study. Pressure pain thresholds in the vulvar area were evaluated in 23 defined locations using a newly developed vulvodolorimeter. Peripheral pressure pain sensitivity was assessed by applying 1) continuously ascending pressures to 3 bilateral locations (thumb, deltoid, and shin), and 2) discrete pressure stimuli to the thumb using both an ascending and random sequence of varying pressures. Pain thresholds at all vulvar locations were lower in the women with vulvodynia than in pain-free control subjects. Similarly, peripheral pain thresholds were lower at the thumb in women with vulvodynia when obtained by discrete ascending or random staircase paradigms, as well as at the thumb, deltoid, and shin when tested by dolorimeter (P <.05). Findings were similar in both those with generalized vulvar dysesthesia and those with localized vestibulodynia. The quantitative results obtained with the vulvodolorimeter and with the...Continue Reading

References

Mar 1, 1992·Pain·R H Gracely
Jun 1, 1996·Annals of Internal Medicine·K L Casey
Jan 10, 1998·American Journal of Obstetrics and Gynecology·J BornsteinH Abramovici
Feb 20, 1998·Pain·Ursula WesselmannLeslie J Heinberg
Sep 1, 1999·Brain : a Journal of Neurology·R PeyronB Laurent
Jun 5, 2002·Pain·Oliver H G Wilder-SmithLars Arendt-Nielsen
Jul 13, 2002·Arthritis and Rheumatism·Richard H GracelyDaniel J Clauw
Feb 12, 2004·Arthritis and Rheumatism·Thorsten GieseckeDaniel J Clauw

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Citations

Mar 20, 2008·Journal of Neurology·Laura BertolasiAlessandra Graziottin
Oct 16, 2009·Archives of Sexual Behavior·Yitzchak M Binik
Nov 8, 2006·Current Pain and Headache Reports·Richard E Harris, Daniel J Clauw
Jan 16, 2010·Journal of Sex Research·Amy D LykinsJillian Minimi
Aug 24, 2006·The Clinical Journal of Pain·Caroline F PukallYitzchak M Binik
Oct 3, 2006·Journal of Lower Genital Tract Disease·Barbara D ReedHope K Haefner
May 25, 2006·Obstetrical & Gynecological Survey·Denniz ZolnounJohn Steege
Nov 17, 2007·Obstetrical & Gynecological Survey·Jennifer Gunter
Aug 22, 2007·The Clinical Journal of Pain·Nina Bohm-StarkeIngela Danielsson
Feb 22, 2008·The Clinical Journal of Pain·Denniz A ZolnounWilliam Maixner
May 20, 2011·The Clinical Journal of Pain·Zheng ZhangMark Tommerdahl
Jan 3, 2012·The Clinical Journal of Pain·Kate S SuttonSusan Chamberlain
Aug 24, 2012·Obstetrics and Gynecology·Barbara D ReedHope K Haefner
Apr 19, 2013·Journal of Lower Genital Tract Disease·Laurie J LegockiBarbara D Reed
Dec 9, 2014·Women's Health·Johanna ThomténSteven Linton
Sep 1, 2007·Women's Health·Caroline F PukallSusan M Chamberlain
May 4, 2013·Women's Health·Johanna Thomtén, Steven J Linton
Mar 25, 2009·Journal of Psychosomatic Obstetrics and Gynaecology·Sophia EhrströmNina Bohm-Starke
Jul 16, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·H L ForthW I Drechsler
Dec 22, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R M MashebR D Kerns
Aug 27, 2013·Gynécologie, obstétrique & fertilité·C de Belilovsky
Jan 28, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marie-Pierre CyrMélanie Morin
Jan 23, 2010·The Journal of Sexual Medicine·Jacques J D M van LankveldChahin Achtrari
Aug 7, 2012·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Heather S Howard
Dec 24, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Douglas E HenryWeibin Yang
Nov 9, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M Moyal-Barracco, J-J Labat
Mar 21, 2007·The Journal of Sexual Medicine·Caroline PukallYitzchak Binik
Dec 17, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Emma FrassonLaura Bertolasi
Mar 14, 2007·Seminars in Arthritis and Rheumatism·Muhammad B Yunus
Jun 18, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·L MichelettiP J Lynch
Sep 2, 2008·European Journal of Pain : EJP·Lone NikolajsenTroels S Jensen
Oct 10, 2012·Arthritis and Rheumatism·Kristine Phillips, Daniel J Clauw
Sep 15, 2012·The Journal of Sexual Medicine·Raphael J Leo, Seema Dewani
Apr 6, 2016·The Journal of Sexual Medicine·Jacob BornsteinUNKNOWN International Pelvic Pain Society (IPPS)
Jun 13, 2014·Human Reproduction Update·Jennifer BrawnKaty Vincent
Mar 6, 2016·The Journal of Sexual Medicine·Caroline F PukallGloria Bachmann
Aug 3, 2014·BMC Urology·J Richard LandisUNKNOWN MAPP Research Network Study Group
Mar 2, 2012·The Journal of Sexual Medicine·Ulrika HeddiniUlrika Johannesson
Jun 8, 2012·The Journal of Sexual Medicine·Rosemary Basson
Mar 16, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Judith M SchlaegerDiana J Wilkie
Mar 18, 2017·American Journal of Obstetrics and Gynecology·Annie MorinMélanie Morin
Oct 19, 2016·Journal of Lower Genital Tract Disease·Barbara D ReedRichard H Gracely

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