Quantitative single-cell RNA-seq with unique molecular identifiers

Nature Methods
Saiful IslamSten Linnarsson

Abstract

Single-cell RNA sequencing (RNA-seq) is a powerful tool to reveal cellular heterogeneity, discover new cell types and characterize tumor microevolution. However, losses in cDNA synthesis and bias in cDNA amplification lead to severe quantitative errors. We show that molecular labels--random sequences that label individual molecules--can nearly eliminate amplification noise, and that microfluidic sample preparation and optimized reagents produce a fivefold improvement in mRNA capture efficiency.

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Related Concepts

Metazoa
Poly(A) Tail
cDNA Library
Sequence Determinations, RNA
MRNA Differential Display
Systems Biology
Mouse, Swiss
Embryonic Stem Cells
High-Throughput Nucleotide Sequencing
Neoplasms

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