PMID: 20650060Feb 1, 1995Paper

Quantitative structure-activity relationships for skin permeability

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M D Barratt

Abstract

In vitro human skin permeability coefficient data collected by Flynn (1990) have been analysed using multiple regression analysis. An improved model for the prediction of permeability coefficients has been derived by the inclusion of the melting point as an independent variable in addition to the octanol-water partition coefficient (as logP) and molecular volume. (The solubility of chemicals in water is related to logP and melting point through an algorithm; Suzuki, Journal of Computer-Aided Molecular Design 1991, 5, 149-166.) Examination of the dataset using principal components analysis confirmed that it could be divided into three distinct groups of chemicals-steroids, other pharmacologically active molecules and small molecules. Regression analysis of the individual groups revealed a very high level of correlation with the model for the steroids and small molecules, but a poor correlation for the pharmacologically active molecules. A sub-set of hydrocortisone derivatives within the steroid group had measured permeability coefficients which were around 1.5 orders of magnitude greater than values predicted from the small molecule model. By grouping together the small molecules and the steroids (excluding the hydrocortisone se...Continue Reading

References

Oct 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R S HinzR H Guy
Oct 1, 1971·The Journal of Pediatrics·R L Nachman, N B Esterly
Aug 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D BarrattD W Roberts

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Citations

Feb 26, 2009·Pharmaceutical Research·Steffi HansenUlrich F Schaefer
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A BasketterM D Barratt
Aug 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M Chamberlain, M D Barratt
Feb 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E WhittleM Chamberlain
Jun 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J N LawrenceD J Benford
Jun 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D Barratt
Jun 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D BarrattP A Jones
Mar 17, 2004·Advanced Drug Delivery Reviews·Gregor Cevc
Apr 15, 2004·Chemosphere·D FitzpatrickB Hayes
Aug 21, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Laura J WatersJohn Stephenson
Jul 17, 2001·The Science of the Total Environment·M O FouchécourtK Krishnan
May 22, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G P MossM T D Cronin
Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D Barratt
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M D BarrattA P Worth
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·O DoucetL Zastrow
Dec 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M HayashiH Kaneko
Mar 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·G Y PatlewiczM D Barratt
Sep 29, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G I PodaE Demchuk
Feb 11, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M T CroninG Murray-Dickson
Feb 24, 2001·Journal of Photochemistry and Photobiology. B, Biology·M D BarrattJ J Langowski
Jun 11, 1998·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·D A Basketter
Jun 27, 2000·Environmental Toxicology and Pharmacology·P SartorelliF Williams
Oct 15, 1996·Environmental Toxicology and Pharmacology·F M Williams
Nov 17, 2009·SAR and QSAR in Environmental Research·M A WarneK P R Gartland
Sep 30, 2003·Journal of Toxicology and Environmental Health. Part a·Richard P Moody, Hart MacPherson
Nov 5, 1997·The Journal of Pharmacy and Pharmacology·M H AbrahamR C Mitchell
Jan 24, 2014·TheScientificWorldJournal·Radka OpatrilovaJosef Jampilek
May 5, 2004·Journal of Pharmaceutical Sciences·Michael H Abraham, Filomena Martins
Feb 4, 2009·Journal of Pharmaceutical Sciences·Brian J NeelyKhaled A M Gasem
Aug 28, 2007·Journal of Pharmaceutical Sciences·Guoping LianLujia Han
Nov 22, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G P MossY Sun
Mar 20, 2015·The Journal of Toxicological Sciences·Tomomi AtobeHirokazu Kouzuki
Feb 5, 2014·Expert Opinion on Drug Metabolism & Toxicology·Yuri G Anissimov
Dec 25, 2012·International Journal of Pharmaceutics·Vishal SachdevaAjay K Banga
Apr 23, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Marta Hidalgo-RodríguezMartí Rosés

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