Quantitative structure-activity relationships studies with micellar electrokinetic chromatography. Influence of surfactant type and mixed micelles on estimation of hydrophobicity and bioavailability

Journal of Chromatography. a
S YangM G Khaledi

Abstract

Applications of micellar electrokinetic chromatography (MEKC) in quantitative structure-activity relationships (QSAR) were studied. First, quantitative structure-retention relationships (QSRR), which describe the correlation between logarithm of capacity factor (log k') in MEKC and logarithm of distribution coefficient between 1-octanol and water (log P(ow)), were investigated for 60 aromatic compounds and 9 corticosteroids using three different anionic surfactants [e.g., sodium dodecyl sulfate (SDS), sodium cholate (SC), and lithium perfluorooctane sulfonate (LiPFOS)], one cationic surfactant (C14TAB), and mixed anionic micellar systems. Linear solvation energy relationships (LSER) and solvatochromic parameters were used to shed light on the different log k' vs. log P(ow) relationships of the various surfactants. It was concluded that hydrogen bonding interactions have a great influence on retention behavior in MEKC and its relationships with hydrophobicity. Interestingly, bile salt surfactants (e.g., SC) and mixed bile salt micellar systems provide better correlations for log k' vs. log P(ow) than SDS and/or SDS with buffer additives (e.g., beta-cyclodextrin, urea, and acetonitrile). Using SC micelles, only one line was adequ...Continue Reading

References

Oct 1, 1994·Electrophoresis·J G Bumgarner, M G Khaledi

❮ Previous
Next ❯

Citations

Dec 31, 1998·Electrophoresis·J PalmerJ P Landers
Feb 3, 2009·Analytical and Bioanalytical Chemistry·Yveline HenchozSophie Martel
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Salwa K Poole, Colin F Poole
Feb 19, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Agnes Taillardat-BertschingerBernard Testa
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·L Escuder-GilabertM J Medina-Hernández
Apr 16, 2005·The Journal of Pharmacy and Pharmacology·Eivor OrnskovStaffan Folestad
Feb 18, 2012·Journal of Chromatographic Science·E DeconinckD Coomans
Nov 6, 2004·Journal of Chromatography. a·J M Bermúdez-SaldañaM L Marina
Jan 22, 2008·Journal of Chromatography. a·Salwa K Poole, Colin F Poole
Aug 31, 2002·Rapid Communications in Mass Spectrometry : RCM·Yining ZhaoEd Maliski
Jun 21, 2006·Electrophoresis·Kevin AltriaCari Sänger-van de Griend
Dec 25, 2008·Electrophoresis·Richie RyanKevin Altria
Mar 2, 2010·Electrophoresis·Yveline HenchozPierre-Alain Carrupt
Dec 1, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·R Kaliszan
Mar 5, 2009·Journal of Medicinal Chemistry·Hong WanAnders G Holmén
Dec 10, 1999·Journal of Pharmaceutical Sciences·Y Ishihama, N Asakawa
May 15, 2007·Journal of Chromatography. a·Károly Héberger
Sep 6, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·C Wei TsaiR Chyu Ruaan
Mar 21, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Suvi-Katriina RuokonenSusanne K Wiedmer
May 23, 2006·Journal of Chemical Information and Modeling·Eric DeconinckYvan Vander Heyden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.