Quantitative structure-retention relationships of cannabimimetic aminoalkilindole derivatives and their metabolites

Journal of Pharmaceutical and Biomedical Analysis
Angelo Antonio D'ArchivioFabrizio Ruggieri

Abstract

Development of chromatographic analyses of synthetic cannabinoids is complicated by the lack of commercial reference standards, especially for new analogues introduced in the clandestine market to bypass legal controls and for their metabolites. In the present work, we explore the possibility of predicting the retention behaviour of the cannabimimetic aminoalkilindoles and their urinary metabolites in high-performance liquid-chromatography using a quantitative structure-retention relationship (QSRR) generated by multilinear regression. To represent the structure of the 43 investigated analytes, 617 computational molecular descriptors are subjected to genetic algorithm variable selection aimed at identifying a small but informative subset. Predictive performance of the QSRR model is evaluated on an external set consisting of 10 representative compounds, including both drugs and their metabolites, and, successively by a Monte Carlo validation method. The best QSRR model, based on six molecular descriptors, exhibits a promising predictive performance and robustness.

References

Dec 6, 1996·Journal of Chromatography. B, Biomedical Applications·C G Georgakopoulos, J C Kiburis
Sep 7, 2004·Analytical and Bioanalytical Chemistry·M ForinaC Pizarro Millan
Apr 11, 2007·Journal of Chromatography. a·M ForinaM Casale
May 15, 2007·Journal of Chromatography. a·Károly Héberger
Mar 29, 2011·Molecular Interventions·Kathryn A SeelyJeffery H Moran
Apr 26, 2012·Current Drug Abuse Reviews·John C Ashton
Jul 28, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Melanie HutterMerja A Neukamm
Jan 22, 2013·Journal of Chromatography. a·Donata FavrettoFranco Tagliaro
Jan 15, 2014·Life Sciences·Mahmoud A ElsohlyMohamed M Radwan

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.