PMID: 501524Sep 1, 1979Paper

Quantitative structure-selectivity relationships: selective drug design

Journal of Pharmaceutical Sciences
A GarziaG Tuccini

Abstract

The concept of complex selectivity (Scn) permits the investigation of quantitative structure--selectivity relationships in the presence of n side effects; Scn permits differentiation of the most selective molecules rather than the most active ones in a congener series. Selectivity quantification in the presence of n side effects facilitates molecular comparisons. The information provided by Scn and its changes with increasing n is discussed. The proposed mathematical model is applied to the study of the selectivity of some antibiotics and antibacterial agents.

Citations

Sep 1, 1985·Environmental Health Perspectives·J M Mayer, H van de Waterbeemd

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