PMID: 7333706Dec 1, 1981Paper

Quantitative studies of natural immunity to solid tumours in rats. NK activity in animals with primary or transplanted spontaneous tumours

International Journal of Cancer. Journal International Du Cancer
G R Flannery, C G Brooks

Abstract

Natural killer (NK) cell activity was measured in a quantitative 6 h chromium release assay using sarcoma MC7 cells as targets. The total NK lytic activity present in the spleen and blood of tumour-bearing animals was compared with the corresponding values for age/sex/parity-matched animals. Rats with primary spontaneous tumours in the breast or subcutaneous sites showed normal levels of NK activity, while rats with primary spontaneous kidney tumours had elevated NK activity, the degree of augmentation being greater with increasing tumour size. A similar elevation of NK activity was generally found in animals with large, transplanted, spontaneous or chemically-induced tumours. This augmentation could only detected when total lytic activity was considered: when NK activity was measured merely on a cell-for-cell basis, it often appeared to be depressed in such animals, in agreement with previous reports. However, with one rapidly metastasizing spontaneous tumour, a real depression of both spleen and blood NK activity was found. Small inocula of cells from non-immunogenic spontaneous mammary tumours or from other non-immunogenic spontaneous tumours caused no early increase in systemic NK activity when injected into the mammary pad...Continue Reading

References

Jul 15, 1975·International Journal of Cancer. Journal International Du Cancer·P HerseyD S Nelson
Jan 1, 1978·Contemporary Topics in Immunobiology·R Kiessling, O Haller
Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·O EreminJ P Stephens
Jan 1, 1978·Advances in Cancer Research·H B Hewitt
May 15, 1979·International Journal of Cancer. Journal International Du Cancer·S K DattaJ J Trentin
Aug 1, 1979·International Journal of Cancer. Journal International Du Cancer·H J Dawkins, G R Shellam
Feb 15, 1978·International Journal of Cancer. Journal International Du Cancer·J R OehlerR B Herberman
Jan 1, 1975·Advances in Cancer Research·O Stutman
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·H F Pross, M G Baines
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·R B HerbermanJ Y Djeu
Jul 15, 1969·International Journal of Cancer. Journal International Du Cancer·R W Baldwin, M J Embleton
May 15, 1966·International Journal of Cancer. Journal International Du Cancer·R W Baldwin
May 15, 1980·International Journal of Cancer. Journal International Du Cancer·M V PimmR W Baldwin
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·G R ShellamH J Dawkins
Mar 15, 1981·International Journal of Cancer. Journal International Du Cancer·H W ZieglerJ M Zarling
Jun 1, 1981·Cellular Immunology·G R FlanneryR W Baldwin
Sep 15, 1980·International Journal of Cancer. Journal International Du Cancer·B GunnR W Baldwin
Apr 17, 1980·Nature·J E TalmadgeJ R Starkey

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