PMID: 6024118May 1, 1967Paper

Quantitative studies of phytohemagglutinin-induced DNA and RNA synthesis in normal and agammaglobulinemic leukocytes

The Journal of Experimental Medicine
D C TormeyH H Fudenberg

Abstract

Leukocytes from nine patients with acquired agammaglobulinemia were studied in vitro. Synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) induced by phytohemagglutinin was measured by determination of the degree of incorporation of labeled precursor. Synthesis of both DNA and RNA was decreased in the agammaglobulinemic cells. The presence of an inhibitor in the patients' sera could not be demonstrated. These results suggest that the basic defect in agammaglobulinemia is cellular rather than humoral.

References

Oct 9, 1965·Lancet·J P Crawford
Jan 18, 1966·Biochimica Et Biophysica Acta·G C Mueller, M L Mahieu
Nov 1, 1962·The Journal of Clinical Investigation·C D WESTN H HOLLAND
Dec 1, 1963·Experimental Cell Research·F BACH, K HIRSCHHORN
Jan 1, 1964·Annual Review of Medicine·J M YOFFEY
Aug 7, 1964·Science·H H FUDENBERG, K HIRSCHHORN
Oct 24, 1964·British Medical Journal·M W ELVESM C ISRAELS
Nov 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·K HIRSCHHORNR H GRUSKIN
Jan 30, 1965·Lancet·P CHARACHEH A ROSENBERG
Apr 1, 1965·The American Journal of Medicine·R D PETERSONR A GOOD
Jul 1, 1965·British Journal of Haematology·N R LINGN WILLIAMSON

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Citations

Jun 11, 1970·The New England Journal of Medicine·R E RocklinJ R David
Jul 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R M KaminS D Douglas
Apr 1, 1970·The American Journal of Medicine·A CruchaudC Ropartz
Jan 1, 1970·The American Journal of Medicine·E V BarnettH J Weinberger
Jun 1, 1969·The American Journal of Medicine·S D DouglasH H Fudenberg
Jan 1, 1982·Clinical Immunology and Immunopathology·A J AmmannR Wedgwood
Aug 1, 1969·Klinische Wochenschrift·E Ambs

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