PMID: 1202992Nov 6, 1975Paper

Quantitative studies of the effect of progesterone on endometrial morphology of the spayed rat

Anatomy and Embryology
I Ljungkvist

Abstract

The effects of various dosages and of various time periods of treatment with progesterone have been studied in the spayed, mature rat. Test objects were the cells of the luminal epithelium and of the endometrial stroma which were examined by qualitative and quantitative electron microscopy. No significant response was observed in epithelial or stromal cells until after 12 hrs of progesterone treatment. The nuclei of both cell types were then more circular than earlier with reduced long diameters. The functional significance of this change in configuration is unclear since only in the stromal cells was it followed by nuclear growth. Further, after 12 hrs of treatment the relative amounts of mitochondria and granular endoplasmic reticulum of stromal cells were reduced while the volume of the stromal cell cytoplasm appeared enlarged. This is taken as evidence that progesterone causes an intracellular oedema probably by decreasing cell membrane permeability. This response is probably not specific for the stroma but also includes the luminal epithelium, although the volume of the epithelial cell cytoplasm could not be determined here. Nucleolar enlargement did occur in stromal cells and was observed after 12 hrs of treatment but was...Continue Reading

References

Jan 1, 1972·Annual Review of Biochemistry·E V Jensen, E R DeSombre
Jan 1, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·I Ljungkvist
Jul 1, 1966·The Journal of Cell Biology·E R WeibelW F Scherle
Aug 1, 1947·Endocrinology·C W HOOKER, T R FORBES

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Citations

Sep 20, 2008·Neuroscience and Behavioral Physiology·G S Solov'evV L Yanin

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