Quantitative studies on the antagonism by naloxone of some narcotic and narcotic-antagonist analgesics

British Journal of Pharmacology
S E Smits, A E Takemori

Abstract

1. Naloxone was used to study the antagonism of the analgesic effects of some narcotics (morphine sulphate, levorphanol tartrate, and methadone hydrochloride) and narcotic antagonists (pentazocine, cyclazocine, and nalorphine hydrochloride). The analgesic assay used was the mouse phenylbenzoquinone stretching test.2. The in vivo equivalent of a pA(2) value (apparent pA(2)) for naloxone was determined with each agonist. These values were found to be significantly larger with the narcotics than with the narcotic antagonists.3. The slopes in the apparent pA(2) plots were also found to be significantly different. It was concluded that this difference in slopes was probably not due to a lack of equilibrium in one of the two groups of analgesics.4. The results suggest that the narcotic and the narcotic-antagonist analgesics may inhibit stretching in this assay by interacting either with two different receptors or with the same receptor in a different manner.

References

Dec 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·H BLUMBERGP S WOLF
Jul 1, 1968·The Journal of Pharmacy and Pharmacology·G F Blane, D Dugdall
May 1, 1967·British Journal of Pharmacology and Chemotherapy·G F BlaneR E Lister
Jun 1, 1954·The Journal of Pharmacy and Pharmacology·A F GREENE WALTON
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Feb 1, 1964·The Journal of Pharmacology and Experimental Therapeutics·A S KEATS, J TELFORD
Apr 1, 1964·British Journal of Pharmacology and Chemotherapy·B M COX, M WEINSTOCK
Jul 20, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·L S HARRIS
Mar 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·H BLUMBERGH B DAYTON
Dec 1, 1947·British Journal of Pharmacology and Chemotherapy·H O SCHILD
Sep 1, 1947·British Journal of Pharmacology and Chemotherapy·H O SCHILD

Citations

Dec 1, 1995·Psychopharmacology·F SierraltaH F Miranda
Sep 1, 1971·European Journal of Pharmacology·G Hayashi, A E Takemori
Oct 1, 1972·European Journal of Pharmacology·A E TakemoriS E Smits
Jun 1, 1974·European Journal of Pharmacology·S I Ankier
Nov 7, 1980·European Journal of Pharmacology·J J Teal, S G Holtzman
Jul 10, 1981·European Journal of Pharmacology·Y ItzhakS Cohen
Feb 18, 1983·European Journal of Pharmacology·A Pazos, J Flórez
Feb 17, 1984·European Journal of Pharmacology·S ViswanathanL Kameswaran
Feb 12, 1985·European Journal of Pharmacology·J L VaughtH I Jacoby
Aug 1, 1976·Pharmacology, Biochemistry, and Behavior·D E Mcmillan, J D Leander
Feb 1, 1978·Pharmacology, Biochemistry, and Behavior·J M Carney, J A Rosecrans
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·J J Teal, S G Holtzman
May 1, 1984·Pharmacology, Biochemistry, and Behavior·N A ZabalaL D Calderon
Apr 1, 1984·Pharmacology, Biochemistry, and Behavior·A ShimadaT Yanagita
Jul 1, 1988·Pharmacology, Biochemistry, and Behavior·M LozadaH Maldonado
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·I Tigerstedt
Oct 25, 1991·Brain Research·A S LevineC J Billington
Apr 1, 1989·The Journal of Pharmacy and Pharmacology·R SandersE G Miller
May 1, 1983·British Journal of Pharmacology·D J BillA M Thompson
Oct 1, 1988·British Journal of Pharmacology·J S ShawK M Burns
Jan 1, 1982·Annals of the New York Academy of Sciences·M W Adler
Nov 21, 1975·Brain Research·H K Proudfit, E G Anderson
Aug 1, 1983·Pain·Meirion B LlewelynMalcolm H T Roberts
Feb 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·C C Hug, T Oka
Dec 29, 2000·Japanese Journal of Pharmacology·S VuckovićR Stojanović
Jan 1, 1976·Annals of the New York Academy of Sciences·A E Takemori
Jun 1, 1971·The International Journal of the Addictions

Related Concepts

Metazoa
Bridged Compounds
Cyclazocine
Tetrahydrofurans
Ketones
Levo-Dromoran
Physeptone
Morphine Sulfate (2: 1), Pentahydrate
Nalorphine, L-tartrate (1: 1)
Narcotic Antagonists

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