PMID: 2510397Jan 1, 1989Paper

Quantitative study of centrolobular hepatic fibrosis in alcoholic disease before cirrhosis

Virchows Archiv. A, Pathological Anatomy and Histopathology
S CauletE Martin

Abstract

In an attempt to determine the importance of perivenular fibrosis (PVF) in alcoholic liver disease, we studied 71 liver biopsies using histological grading and a morphometric method. The histological grading used 7 variables which allowed us to classify the patients into 7 groups: controls, patients without alcoholic hepatitis but with steatosis, steato-fibrosis, portal fibrosis and patients with mild, moderate, or severe alcoholic hepatitis. The quantitative analysis examined 3 parameters: (1) The inner diameter of the terminal hepatic veins (THV). (2) The thickness of the THV rims, related to perivenular fibrosis (PVF). (3) Centrolobular fibrosis (CLF) which represented the association of perivenular and perisinusoidal centrolobular fibrosis. No changes in the inner diameter of the terminal hepatic veins was observed for the different groups except in the case of severe alcoholic hepatitis. This fact indicated the absence of veno-occlusive lesions in early stages of mild and moderate alcoholic disease. In severe alcoholic hepatitis, THV were destroyed by centrolobular scars and most of them were indistinguishable and unmeasurable. Of the 26 cases with steatosis (with or without portal fibrosis) only two cases with steatofibro...Continue Reading

References

Jun 1, 1978·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·L C JunqueiraR Brentani
Dec 10, 1977·British Medical Journal·L Van Waes, C S Lieber
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·L C PortoJ A Grimaud
Jan 1, 1986·Journal of Clinical Pathology·A D Burt, R N MacSween
Aug 2, 1985·JAMA : the Journal of the American Medical Association·T M Worner, C S Lieber

❮ Previous
Next ❯

Citations

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·M S de AraújoJ A Grimaud
Sep 1, 1993·Baillière's Clinical Gastroenterology·D J Harrison, A D Burt
Feb 1, 1991·Alcoholism, Clinical and Experimental Research·K G IshakM B Ray
May 23, 2002·Journal of the American Veterinary Medical Association·Terri L ColeHollis N Erb
Aug 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ChevallierJ A Grimaud
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A R CrawfordJ M Crawford
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Michel Henry MendlerSugantha Govindarajan
Sep 8, 2010·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Si Eun HwangWataru Kimura
Nov 18, 2015·World Journal of Gastroenterology : WJG·Randy LiangAijaz Ahmed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
P Aisen
Virchows Archiv. A, Pathological Anatomy and Histopathology
K A Bardadin, P J Scheuer
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M C LaiS D Lee
© 2022 Meta ULC. All rights reserved