PMID: 1199930Nov 1, 1975Paper

Quantitative study of left bundle branch fibrosis in left anterior hemiblock: A stereologic approach

The American Journal of Cardiology
J C DemoulinH Kulbertus

Abstract

Serial sectioning of the interventricular septum was carried out in 16 hearts, 8 from elderly subjects with no conduction disturbance and 8 from patients with chronic left anterior hemiblock. The histologic slides were studied stereologically, and the relative density of fibrosis was quantitatively assessed by the point counting technique at various levels of the main subdivisions of the left bundle branch system. Statistical analysis revealed the following: (1) Although some fibrosis was found in the control hearts, the density of fibrosis was consistently and significantly greater throughout the conduction system in patients with left anterior hemiblock. (2) In the group with hemiblock, the relative density of fibrosis tended to increase significantly from the posterior ramification to the midseptal fibers and, finally, to the anterior fascicle. (3) Among the eight patients with hemiblock, fibrosis appeared to be evenly distributed throughout the conduction system in four. It was predominantly located in the anterior and midseptal fibers in one patient and showed an increasing severity from the posterior to the midseptal and anterior fibers in the remaining three patients. From this quantitative study, it is concluded that le...Continue Reading

References

Feb 1, 1973·The American Journal of Cardiology·H H HechtT B Watt
Dec 1, 1972·The American Journal of Cardiology·H N Uhley
Nov 1, 1973·American Heart Journal·J C Demoulin, H E Kulbertus
Aug 1, 1967·American Heart Journal·M L EntmanD B Hackel
Aug 1, 1972·British Heart Journal·J C Demoulin, H E Kulbertus
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Jun 1, 1970·Circulation·D DurrerR C Arzbaecher
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May 1, 1965·American Heart Journal·T B WATT, R D PRUITT

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Citations

Mar 1, 1979·The American Journal of Cardiology·S W RabkinR B Tate
Aug 9, 2003·Journal of the American College of Cardiology·Xander A A M VerbeekFrits W Prinzen
Aug 16, 2002·Clinics in Geriatric Medicine·John P Bourke
May 1, 1978·British Heart Journal·R A CorneR L Rollwagen
Jun 1, 1985·British Heart Journal·D B ShawT Whistance
Jan 1, 1991·British Heart Journal·Y ChandrashekharI S Anand
Aug 1, 1979·The American Journal of Cardiology·E LichsteinK D Chadda
Oct 1, 1979·The American Journal of Cardiology·C R WyndhamK M Rosen
Nov 1, 1979·The American Journal of Cardiology·J C Demoulin, H E Kulbertus
Jul 1, 1979·American Heart Journal·R ThompsonM Yacoub
Oct 1, 1977·American Heart Journal·L B JacobsonK Cohn
Jul 28, 2016·The American Journal of Cardiology·Kaylin T NguyenGregory M Marcus
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·Lisa Sattenspiel, Carlos Castillo-Chavez

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