Quantitative susceptibility mapping of small objects using volume constraints.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
S LiuE Mark Haacke

Abstract

Microbleeds have been implicated to play a role in many neurovascular and neurodegenerative diseases. The diameter of each microbleed has been used previously as a possible quantitative measure for grading microbleeds. We propose that magnetic susceptibility provides a new quantitative measure of extravasated blood. Recently, a Fourier-based method has been used that allows susceptibility quantification from phase images for any arbitrarily shaped structures. However, when very small objects, such as microbleeds, are considered, the accuracy of this susceptibility mapping method still remains to be evaluated. In this article, air bubbles and glass beads are taken as microbleed surrogates to evaluate the quantitative accuracy of the susceptibility mapping method. We show that when an object occupies only a few voxels, an estimate of the true volume of the object is necessary for accurate susceptibility quantification. Remnant errors in the quantified susceptibilities and their sources are evaluated. We show that quantifying magnetic moment, rather than the susceptibility of these small structures, may be a better and more robust alternative.

References

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Citations

May 2, 2014·Journal of Magnetic Resonance Imaging : JMRI·Jaladhar NeelavalliMoriah E Thomason
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sagar BuchE Mark Haacke
Sep 25, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ying DongJim X Ji
Oct 1, 2014·Magnetic Resonance Imaging·E Mark HaackeYongquan Ye
Dec 10, 2014·Magnetic Resonance Imaging·Yu-Chung N ChengGavin Lawes
Jan 31, 2015·Magnetic Resonance Imaging·Ching-Yi HsiehR Jason Stafford
Jul 22, 2017·Journal of Magnetic Resonance Imaging : JMRI·Saifeng LiuYulin Ge
Dec 18, 2018·Recent Patents on Biotechnology·Feng LinYi Wang
Feb 28, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·José P MarquesFerdinand Schweser

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