Quantitative T2 MRI Mapping and 12-Month Follow-up in a Randomized, Blinded, Placebo Controlled Trial of Bone Marrow Aspiration and Concentration for Osteoarthritis of the Knees

Cartilage
Shane A ShapiroMary I O'Connor

Abstract

Bone marrow aspiration and concentration (BMAC) is becoming a more common regenerative therapy for musculoskeletal pathology. In our current pilot study, we studied patients with mild-to-moderate bilateral knee osteoarthritis, compared pain at 12-month follow-up between BMAC-injected and saline-injected knees, and examined cartilage appearance measured by magnetic resonance imaging (MRI) T2 quantitative mapping. Twenty-five patients with mild-to-moderate bilateral osteoarthritic knee pain were randomized to receive BMAC into one knee and saline placebo into the other. Bone marrow was aspirated from the iliac crests, concentrated in an automated centrifuge, combined with platelet-poor plasma for knee injection, and compared with saline injection into the contralateral knee. Primary outcome measures were T2 MRI cartilage mapping at 6-month and Visual Analog Scale and Osteoarthritis Research Society International Intermittent and Constant Osteoarthritis Pain scores and radiographs at 12-month follow-up. Constant, intermittent, and overall knee pain remained significantly decreased from baseline at 12-month follow-up (all P ⩽ 0.01), with no apparent difference between BMAC- and saline-treated knees (all P ⩾ 0.54). A similar signifi...Continue Reading

References

Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Apr 2, 1999·Science·M F PittengerD R Marshak
Jul 4, 2001·Journal of Magnetic Resonance Imaging : JMRI·H E SmithM B Smith
Dec 5, 2002·Osteoarthritis and Cartilage·C LiessC-C Glüer
Jan 12, 2005·Seminars in Musculoskeletal Radiology·Timothy J Mosher, Bernard J Dardzinski
May 5, 2006·Clinical Orthopaedics and Related Research·Carlos LaverniaVictor Hugo Hernandez
Aug 10, 2006·Journal of Magnetic Resonance Imaging : JMRI·Denis Le BihanFranck Lethimonnier
Jan 30, 2007·Experimental Hematology·Tarja A JuopperiSaul J Sharkis
Feb 3, 2007·The Journal of Bone and Joint Surgery. American Volume·Martin S SchulzMichael J Strobel
Apr 4, 2007·The Journal of Bone and Joint Surgery. American Volume·Steven KurtzMichael Halpern
Jul 11, 2007·Journal of Cellular Physiology·Arnold I Caplan
Jul 16, 2008·Acta Orthopaedica·Shinisuke SakaiNaoyuki Ochiai
Sep 2, 2008·Arthritis and Rheumatism·Louise MurphyJoanne M Jordan
Oct 25, 2008·Arthritis Research & Therapy·Faye H Chen, Rocky S Tuan
Jun 8, 2010·Cell Transplantation·Hiroshi YagiMartin L Yarmush
Apr 27, 2011·International Journal of Rheumatic Diseases·Fereydoun DavatchiBehrooz Nikbin
Jul 6, 2011·Cell Stem Cell·Arnold I Caplan, Diego Correa
Apr 4, 2012·Osteoarthritis and Cartilage·B BittersohlC Zilkens
Jul 4, 2012·Annals of the Rheumatic Diseases·David FelsonMichael C Nevitt
Oct 13, 2012·Osteoarthritis and Cartilage·A P PrasadT M Link
Dec 6, 2012·The American Journal of Sports Medicine·Amy S WasterlainJason L Dragoo
Feb 5, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Yong-Gon KohYun-Jin Choi
May 18, 2013·Transplantation·Lluis OrozcoJavier García-Sancho
Jul 3, 2013·Mayo Clinic Proceedings·Andre Terzic, Timothy J Nelson
Dec 12, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Yong-Gon KohJee-Eun Yeo
Jan 9, 2014·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Jae-Do KimYoung-Bin You
Jul 7, 2015·International Journal of Molecular Sciences·Onju HamWoochul Chang
Sep 5, 2015·BMC Musculoskeletal Disorders·Kazunari KurodaHiroyuki Tsuchiya
Sep 10, 2015·The New England Journal of Medicine·Hermes Taylor-Weiner, Joshua Graff Zivin
Jan 13, 2016·Stem Cell Research & Therapy·Johannes Leibacher, Reinhard Henschler
Mar 2, 2016·Clinics in Orthopedic Surgery·Philippe HernigouCharles-Henri Flouzat-Lachaniette
Mar 15, 2016·Osteoarthritis and Cartilage·M K MamidiR Bhonde

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Citations

Jan 18, 2019·Regenerative Medicine·Shane A ShapiroZubin Master
Jul 12, 2019·Cartilage·Shane A ShapiroMary I O'Connor
Nov 14, 2019·International Journal of Molecular Sciences·Fabio S M YamaguchiRoberta S Stilhano
Jan 3, 2021·Musculoskeletal Care·Lok Sze LeeKwong Yuen Chiu
Feb 26, 2021·Stem Cells International·Shuangpeng JiangQuanyi Guo
Mar 9, 2021·Therapeutic Advances in Musculoskeletal Disease·Isabel Andia, Nicola Maffulli
Dec 15, 2020·Techniques in Vascular and Interventional Radiology·Robert L BowersKenneth R Mautner
Apr 27, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Wenli DaiYingfang Ao
May 28, 2021·British Journal of Sports Medicine·Tom Gh WiggersMaarten H Moen
Jul 17, 2021·EFORT Open Reviews·Gerardo FuscoElizaveta Kon
Jul 9, 2021·The American Journal of Sports Medicine·Laura E KeelingWilliam F Postma
Aug 7, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Derrick M KnapikBrian J Cole
Feb 5, 2022·Current Reviews in Musculoskeletal Medicine·Anne KuwabaraSeth Lawrence Sherman

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Methods Mentioned

BETA
bone marrow aspiration
bone marrow aspirations
flow cytometry

Software Mentioned

SAS
R Foundation
R
JTECH Medical tracker system
CARTILAGE

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