Quantitative three-dimensional elasticity imaging from quasi-static deformation: a phantom study

Physics in Medicine and Biology
Michael S RichardsAssad A Oberai

Abstract

We present a methodology to image and quantify the shear elastic modulus of three-dimensional (3D) breast tissue volumes held in compression under conditions similar to those of a clinical mammography system. Tissue phantoms are made to mimic the ultrasonic and mechanical properties of breast tissue. Stiff lesions are created in these phantoms with size and modulus contrast values, relative to the background, that are within the range of values of clinical interest. A two-dimensional ultrasound system, scanned elevationally, is used to acquire 3D images of these phantoms as they are held in compression. From two 3D ultrasound images, acquired at different compressed states, a three-dimensional displacement vector field is measured. The measured displacement field is then used to solve an inverse problem, assuming the phantom material to be an incompressible, linear elastic solid, to recover the shear modulus distribution within the imaged volume. The reconstructed values are then compared to values measured independently by direct mechanical testing.

References

Jan 1, 1997·Radiology·B S GarraM F Pennanen
Jun 28, 2000·Physics in Medicine and Biology·M M DoyleyJ C Bamber
Jun 28, 2000·Physics in Medicine and Biology·D D SteeleS Y Emelianov
Jul 18, 2002·Physics in Medicine and Biology·Paul E Barbone, Jeffrey C Bamber
Apr 23, 2003·Ultrasound in Medicine & Biology·Timothy J HallCandace S Spalding
Aug 3, 2004·Physics in Medicine and Biology·Assad A OberaiJeffrey C Bamber
Jun 7, 2005·Ultrasound in Medicine & Biology·Marvin M DoyleyJonathan Ophir
Feb 18, 2006·Radiology·Ako ItohTakeshi Matsumura
Apr 18, 2006·Ultrasound in Medicine & Biology·Joel E LindopRichard W Prager
Aug 16, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A ThomasS Kümmel
Dec 26, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Chikayoshi Sumi
May 29, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hui ZhiHai-Yun Yang
Oct 18, 2007·Radiology·Elizabeth S BurnsideNicholas J Hangiandreou
Nov 13, 2007·Ultrasound in Medicine & Biology·Graham M TreeceRichard W Prager
Dec 8, 2007·Reproductive Biomedicine Online·C Y FongA Bongso
Jan 1, 1996·IEEE Transactions on Medical Imaging·F Kallel, M Bertrand

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Citations

Nov 1, 2011·Physics in Medicine and Biology·M S Richards, M M Doyley
Jan 10, 2012·Physics in Medicine and Biology·M M Doyley
Oct 21, 2011·Journal of Biomechanical Engineering·Ramesh RaghupathyVictor H Barocas
Apr 10, 2012·Medical Physics·Syeda Naema Bhatti, Mallika Sridhar-Keralapura
Sep 10, 2014·Biomedical Engineering Online·Xiaochang PanJianwen Luo
Jan 25, 2014·Ultrasound Clinics·M M Doyley, K J Parker
Jun 1, 2010·Ultrasound in Medicine & Biology·Ted G FisherSteve Barnes
Dec 15, 2015·Journal of Biomechanics·Ruth L ChimentiMichael S Richards
Mar 10, 2016·IEEE Transactions on Biomedical Circuits and Systems·Zhaohong ChenQinghua Huang
Aug 19, 2011·IEEE Transactions on Bio-medical Engineering·Jorn op den BuijsSarthak Misra
Jun 6, 2012·IEEE Transactions on Medical Imaging·Sevan GoenezenAssad A Oberai
Jul 31, 2014·International Journal for Numerical Methods in Biomedical Engineering·Mohit TyagiAssad A Oberai
Feb 1, 2011·Ultrasound in Medicine & Biology·R James HousdenJeffrey C Bamber
Jan 22, 2013·Procedia IUTAM·Amira I HusseinElise F Morgan
Aug 3, 2016·IEEE Transactions on Medical Imaging·Clement PapadacciElisa E Konofagou
May 10, 2017·Sensors·Yue MeiSevan Goenezen
Mar 13, 2015·Ultrasonic Imaging·Bonghun ShinHyock Ju Kwon
Jan 30, 2019·Physics in Medicine and Biology·Ligin M SolamenKeith D Paulsen
Feb 27, 2019·Physics in Medicine and Biology·Matthew McGarryKeith Paulsen
Feb 12, 2020·Physics in Medicine and Biology·Cameron HoerigMichael F Insana
Dec 30, 2016·Physics in Medicine and Biology·K GijsbertseC L de Korte
Mar 19, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·William J Parnell, Riccardo De Pascalis
Mar 12, 2013·Physics in Medicine and Biology·Hirad KarimiAbbas Samani
Dec 19, 2017·Inverse Problems in Science and Engineering·Olalekan A BabaniyiPaul E Barbone
May 1, 2020·Scientific Reports·Md Tauhidul IslamRaffaella Righetti
Jan 4, 2017·The Review of Scientific Instruments·Xin XuWan Y Shih

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