Quantitative trait loci for resistance to Heligmosomoides bakeri and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

Parasitology
Jerzy M BehnkeJohn P Gibson

Abstract

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to Heligmosomoides bakeri. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to H. bakeri is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

References

Feb 1, 1987·International Journal for Parasitology·G A Albers, G D Gray
Aug 2, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F IraqiA J Teale
Apr 24, 2002·Antioxidants & Redox Signaling·Jun WangSamuel J Black
Mar 21, 2003·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Fuad A IraqiDerek R Wakelin
May 21, 2003·Journal of Helminthology·J M BehnkeD Wakelin
Sep 15, 2004·Trends in Parasitology·Ray M Kaplan
Jan 1, 1991·Parasitology Today·J M BehnkeJ W Lewis
Oct 1, 1992·Parasitology Today·A KloostermanH W Ploeger
Dec 17, 2004·Genetics, Selection, Evolution : GSE·Sonja Dominik
Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·O Delphin KoudandéFuad Iraqi
Oct 8, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Petra SchaaffUwe Holzwarth
Jun 20, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jerzy M BehnkeJohn P Gibson
Aug 8, 2006·International Journal for Parasitology·John Stuart Gilleard
Nov 2, 2006·Parasitology·M J StearK Donskow-Schmelter
Dec 19, 2006·Nature Reviews. Genetics·Luanne L PetersKaren L Svenson
Sep 2, 2008·Annual Review of Genetics·Kent W Hunter, Nigel P S Crawford

❮ Previous
Next ❯

Citations

Sep 28, 2014·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Rohan ShahB Emma Huang
Nov 4, 2016·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Hanifa J Abu-Toamih AtamniFuad A Iraqi
Feb 21, 2018·Frontiers in Immunology·Simon A BabayanAmy B Pedersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.