Quantitative trait loci on chromosome 5 for susceptibility to frequency-specific effects on hearing in DBA/2J mice

Experimental Animals
Sari SuzukiYoshiaki Kikkawa

Abstract

The DBA/2J strain is a model for early-onset, progressive hearing loss in humans, as confirmed in the present study. DBA/2J mice showed progression of hearing loss to low-frequency sounds from ultrasonic-frequency sounds and profound hearing loss at all frequencies before 7 months of age. It is known that the early-onset hearing loss of DBA/2J mice is caused by affects in the ahl (Cdh23(ahl)) and ahl8 (Fscn2(ahl8)) alleles of the cadherin 23 and fascin 2 genes, respectively. Although the strong contributions of the Fscn2(ahl8) allele were detected in hearing loss at 8- and 16-kHz stimuli with LOD scores of 5.02 at 8 kHz and 8.84 at 16 kHz, hearing loss effects were also demonstrated for three new quantitative trait loci (QTLs) for the intervals of 50.3-54.5, 64.6-119.9, and 119.9-137.0 Mb, respectively, on chromosome 5, with significant LOD scores of 2.80-3.91 for specific high-frequency hearing loss at 16 kHz by quantitative trait loci linkage mapping using a (DBA/2J × C57BL/6J) F1 × DBA/2J backcross mice. Moreover, we showed that the contribution of Fscn2(ahl8) to early-onset hearing loss with 32-kHz stimuli is extremely low and raised the possibility of effects from the Cdh23(ahl) allele and another dominant quantitative tra...Continue Reading

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Citations

Jun 21, 2015·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kenneth R JohnsonLeona H Gagnon
Apr 4, 2021·International Journal of Molecular Sciences·Judit SzepesyTibor Zelles

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

R
GraphPad
qtl
GraphPad Prism
R Statistical package

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