Quantitative two-dimensional photoacoustic tomography of osteoarthritis in the finger joints

Optics Express
Jiaying XiaoHuabei Jiang

Abstract

We present for the first time in vivo experimental evidence that quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a PAT scanner. Tissue absorption coefficient images of all the examined joints, which were unavailable from the conventional PAT, were recovered using our finite element based qPAT approach. The recovered quantitative photoacoustic images revealed significant differences in the tissue absorption coefficient of the joint cavity (cartilage and synovial fluid) between the OA and normal joints.

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Citations

Oct 4, 2011·IEEE Transactions on Medical Imaging·Andreas H HielscherJürgen Beuthan
Feb 1, 2011·Ultrasound in Medicine & Biology·Xueding WangPaul L Carson
Nov 29, 2016·Journal of Biomedical Optics·Paul Kumar Upputuri, Manojit Pramanik
Jan 29, 2016·Annals of Biomedical Engineering·Joseph M MansourJean F Welter
Mar 28, 2019·Journal of Biophotonics·Jinge YangHuabei Jiang
Nov 6, 2020·Biomedical Optics Express·Idit FederDror Fixler
Apr 14, 2021·Osteoarthritis and Cartilage·M WuR G P Lopata

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