Quantitative ultrasonometry of the calcaneus in children with osteogenesis imperfecta

Journal of Paediatrics and Child Health
Stepan Kutilek, Milan Bayer

Abstract

Osteogenesis imperfecta (OI) is characterised by low bone density and increased bone fragility. The aim was to evaluate calcaneal quantitative ultrasonometry (QUS) parameters in children with OI and to look for relationship with the number of prevalent fractures. Eighteen children (12 boys and six girls; mean age 9.8 ± 3.5 years) with OI (type I, n= 15; type IV, n= 3; mean fracture prevalence 3.7 per patient) had the velocity of sound (VOS) and broadband ultrasound attenuation (BUA) measured on both heels with a Cuba Clinical (McCue Ultrasonics, Winchester, UK) dry ultrasound portable device. Both BUA and VOS were expressed as either age-dependent or height-related values. The obtained values of VOS and BUA were correlated to number of prevalent fractures. The patients were of short stature (Z-score -1.73 ± 1.20 SD; P < 0.001). Both age-related BUA and VOS were low in comparison to reference values (P < 0.0001), same as height-adjusted BUA and VOS (P < 0.0001). We found no correlations between number of prevalent fractures and BUA or VOS (age-related or height-adjusted) (r= 0.02, r= 0.017, r=-0.13, r= 0.015, respectively). Children with OI have low QUS parameters with no relationship to number of prevalent fractures.

References

Apr 1, 1979·Journal of Medical Genetics·D O SillenceD M Danks
Jun 1, 1997·Archives of Disease in Childhood·M Z MughalC M Langton
Feb 12, 1998·Calcified Tissue International·M Bayer, S Kutílek
Aug 3, 1999·Calcified Tissue International·C CepollaroC Gennari
Jan 26, 2002·Eating and Weight Disorders : EWD·S Kutílek, M Bayer
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Frank RauchFrancis H Glorieux
Jun 7, 2003·Acta Odontologica Scandinavica·Barbro Malmgren, Sven Lindskog
Oct 17, 2003·European Cells & Materials·P J RoughleyF H Glorieux
Apr 14, 2004·Neonatal Network : NN·Kathryn R McLean
Apr 28, 2004·Lancet·Frank Rauch, Francis H Glorieux
Jun 8, 2006·The Journal of Bone and Joint Surgery. American Volume·Robert P HuangRichard J Haynes
Apr 30, 2008·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Marc-Antoine KriegDidier Hans

❮ Previous
Next ❯

Citations

Jun 8, 2014·Italian Journal of Pediatrics·Stefano StagiMaria Luisa Brandi
Apr 12, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K D WilliamsB Towne

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.