Quantitative ultrasound spectroscopic imaging for characterization of disease extent in prostate cancer patients

Translational Oncology
Ali Sadeghi-NainiGregory J Czarnota

Abstract

Three-dimensional quantitative ultrasound spectroscopic imaging of prostate was investigated clinically for the noninvasive detection and extent characterization of disease in cancer patients and compared to whole-mount, whole-gland histopathology of radical prostatectomy specimens. Fifteen patients with prostate cancer underwent a volumetric transrectal ultrasound scan before radical prostatectomy. Conventional-frequency (~5MHz) ultrasound images and radiofrequency data were collected from patients. Normalized power spectra were used as the basis of quantitative ultrasound spectroscopy. Specifically, color-coded parametric maps of 0-MHz intercept, midband fit, and spectral slope were computed and used to characterize prostate tissue in ultrasound images. Areas of cancer were identified in whole-mount histopathology specimens, and disease extent was correlated to that estimated from quantitative ultrasound parametric images. Midband fit and 0-MHz intercept parameters were found to be best associated with the presence of disease as located on histopathology whole-mount sections. Obtained results indicated a correlation between disease extent estimated noninvasively based on midband fit parametric images and that identified histo...Continue Reading

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Citations

Dec 29, 2019·Scientific Reports·Elham KaramiAli Sadeghi-Naini
Mar 27, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tsukasa IshiwataKoichiro Tatsumi
Aug 25, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Isabelle DurotAhmed El Kaffas

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