Quantitative vapor delivery for improved canine threshold testing.

Analytical and Bioanalytical Chemistry
Lauryn E DeGreeffStephanie Vaughan

Abstract

The canine olfactory system is a highly efficient and intricate tool often exploited by humans for detection for its many attributes, including impressive sensitivity to trace analyte vapors. Canine detectors are often touted as having lower limits of detection, or olfactory detection threshold (ODT), than other field-relevant detection technologies; however, previous attempts to quantify canine ODTs have resulted in reported estimates spanning multiple orders of magnitude, even for the same analyte. A major contributor to these discrepancies is the vapor delivery method used for testing, where losses due to adsorption and dilution are often unaccounted for, and the presence of unattended compounds in the vapor stream due to carryover may go unnoticed. In this research, a trace vapor generator (TV-Gen) was used to deliver quantitatively accurate amounts of vapor reproducibly over time for canine testing. Analyte losses due to adsorption to surfaces in the flow path, dilution in the sniff port at the outlet, and analyte carryover were considered. Computational fluid dynamic (CFD) modeling was used to visualize analyte vapor spread throughout the port. CFD simulations revealed the need for a diffuser to encourage the diffusion of...Continue Reading

References

Jan 1, 1984·Neuroscience and Biobehavioral Reviews·D KrestelL Jonsson
Mar 19, 2014·Forensic Science International : Synergy·Tadeusz JezierskiEugene Papet
Apr 14, 2016·Physiological Research·M WackermannováL Jebavý
Jan 4, 2017·Rhinology·A SorokowskaT Hummel
Apr 5, 2017·The Review of Scientific Instruments·Greg E CollinsSusan L Rose-Pehrsson
Feb 7, 2019·Frontiers in Veterinary Science·Astrid R ConchaDaniel S Mills
Sep 3, 2020·The Review of Scientific Instruments·Braden C GiordanoSusan L Rose-Pehrsson

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