PMID: 6172533Dec 1, 1981Paper

Quantitative variations in the expression of H-2 antigens on murine leukemia virus-induced tumor cells can affect the H-2 restriction patterns of tumor-specific cytolytic T lymphocytes

The Journal of Experimental Medicine
F PlataF Lilly

Abstract

Comparative quantitative experiments were designed to study the expression of H-2Kd and H-2Dd antigens on three different leukemia cell lines induced by Gross murine leukemia virus (MuLV)in BALB/c (H-2d) mice. The H-2 restriction patterns of syngeneic cytolytic T lymphocytes (CTL) directed against Gross MuLV-induced tumors were correlated with these quantitations of H-2Kd and H-2Dd antigens, Our results obtained by quantitative absorption of monospecific antisera indicated that the three BALB/c tumor cell lines expressed different amounts of H-2Kd and H-2Dd antigens, with H-2Dd antigen showing the greatest variability in expression because it ranged from barely detectable levels to one-eighth the amount of H-2Dd antigen expressed on normal BALB/c spleen cells. The H-2 restriction patterns of Gross MuLV-specific CTL were directly affected by these quantitative modulations in the expression of H-2Kd and H-2Dd antigens, as revealed by three independent approaches: (a) inhibition of CTL activity by monospecific anti-H-2 sera in the absence of complement; (b)competitive inhibition of CTL-mediated cytotoxicity by the addition of excess tumor cells into the reaction mixture; and (c) analysis of CTL specificities using cloned CTL popul...Continue Reading

References

Jul 1, 1975·The Journal of Experimental Medicine·H A Freedman, F Lilly
Apr 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·L GROSS

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Citations

Oct 28, 1986·Biochimica Et Biophysica Acta·M Zijlstra, C J Melief
Nov 1, 1985·The Journal of Experimental Medicine·L H ShapiroJ E Neiderhuber
Apr 1, 1986·Journal of Immunogenetics·P Demant
Apr 1, 1986·Journal of Immunogenetics·W SchmidtU Henseling
Mar 1, 1997·Family Process·M A Lewinsohn, P D Werner
Jul 1, 1986·European Journal of Immunology·A Schäfer, W Schmidt
Dec 1, 1988·European Journal of Immunology·F MichelF Plata
Feb 15, 1986·International Journal of Cancer. Journal International Du Cancer·M Oudshoorn-Snoek, P Demant
Jan 15, 1985·International Journal of Cancer. Journal International Du Cancer·N Kiger
Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·E M SchneiderP Wernet

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