Quantitative Vertebral Bone Density Seen on Chest CT in Chronic Obstructive Pulmonary Disease Patients: Association with Mortality in the Korean Obstructive Lung Disease Cohort

Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Hye Jeon HwangYeon Mok Oh

Abstract

Patients with chronic obstructive pulmonary disease (COPD) are known to be at risk of osteoporosis. The purpose of this study was to evaluate the association between thoracic vertebral bone density measured on chest CT (DThorax) and clinical variables, including survival, in patients with COPD. A total of 322 patients with COPD were selected from the Korean Obstructive Lung Disease (KOLD) cohort. DThorax was measured by averaging the CT values of three consecutive vertebral bodies at the level of the left main coronary artery with a round region of interest as large as possible within the anterior column of each vertebral body using an in-house software. Associations between DThorax and clinical variables, including survival, pulmonary function test (PFT) results, and CT densitometry, were evaluated. The median follow-up time was 7.3 years (range: 0.1-12.4 years). Fifty-six patients (17.4%) died. DThorax differed significantly between the different Global Initiative for Chronic Obstructive Lung Disease stages. DThorax correlated positively with body mass index (BMI), some PFT results, and the six-minute walk distance, and correlated negatively with the emphysema index (EI) (all p < 0.05). In the univariate Cox analysis, older a...Continue Reading

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Citations

Aug 7, 2021·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Mehmet TahtabasiFatih Sahiner
Aug 26, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Seong Ho ParkSeo Young Park

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Methods Mentioned

BETA
X-ray
ESR

Software Mentioned

Aview
SPSS

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