PMID: 9179769Jun 1, 1997Paper

Quantity of cytomegalovirus viruria is a major risk factor for cytomegalovirus disease after renal transplantation

Journal of Medical Virology
A V CopeV C Emery

Abstract

Studies have shown that risk factors for human cytomegalovirus (HCMV) disease after renal transplant include primary infection (virus of donor origin infecting a non-immune individual), re-infection (virus of donor origin infecting a immune individual), and the detection of viraemia (as a marker of virus dissemination). We now report that viral load in the urine is also a significant factor in HCMV disease and is one of the main mechanisms underlying the risk associated with viraemia and donor serostatus. Longitudinal analysis of a group of 196 renal recipient identified 35 recipients who were PCR positive for HCMV in urine. Elevated viral loads were present in symptomatic patients, viraemic patients, and patients experiencing primary HCMV infection. Disease was associated with the peak quantity of virus present in the urine during the post-transplant period (P = 0.0001), with viraemia (P = 0.0003), and with transplantation of a seropositive donor (P = 0.03). Univariate logistic regression analysis showed that increases of 0.25 log10 in viral load were associated with a 179% increased risk of disease (odds ratio = 2.79; 95% C.I. 1.22-6.39; P = 0.02). This effect persisted in a multivariate logistic analysis when viraemia was in...Continue Reading

Citations

Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P D GriffithsV C Emery
Aug 4, 1999·The Journal of Experimental Medicine·V C EmeryP D Griffiths
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·V C Emery, P D Griffiths
Jan 6, 2001·Sexually Transmitted Infections·J R Deayton
Feb 24, 2001·Journal of Clinical Pathology·V C Emery
Apr 12, 2007·Clinical Transplantation·Jay A FishmanMarc E Uknis

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