Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression

Investigative Ophthalmology & Visual Science
Marco NassisiSriniVas R Sadda

Abstract

The purpose of this study was to evaluate the correlation between quantity of intraretinal hyperreflective foci (HRF) in the eye with intermediate AMD and progression to late AMD. Volume optical coherence tomography (OCT) scans from 114 eyes of 114 patients were retrospectively reviewed. HRF were assessed both qualitatively and quantitatively. Five sequential en face slabs from midretina were thresholded to isolate the HRF. These five slabs were recombined, and HRF area was measured in the whole 6 × 6-mm image (HRFTOT) and within the central 3-mm (HRF3mm) and 5-mm (HRF5mm) regions. These measurements were correlated with the development of late AMD (defined as choroidal neovascularization [CNV] and/or complete RPE and photoreceptor atrophy [cRORA]) after 1 year of follow-up. HRF area in all three regions showed significant correlations with progression to late AMD: R = 0.610 for HRF3mm, R = 0.622 for HRF5mm, and R = 0.614 for HRFTOT (all P < 0.001). Correlations remained significant with progression to cRORA alone, though not for progression to CNV alone. While qualitative assessment of HRF (i.e., presence of HRF: yes or no) also showed a significant correlation with progression to late AMD (R = 0.454, P < 0.001) and atrophy al...Continue Reading

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Citations

Feb 27, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Thomas J HeesterbeekAnneke I den Hollander
Jun 24, 2020·Investigative Ophthalmology & Visual Science·Maria V CastanosToco Y P Chui
Jul 3, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marco NassisiSrinivas R Sadda
Jul 30, 2019·Retina·Vivian SchreurCarel B Hoyng
Sep 3, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Vasilena SitnilskaLebriz Altay
Dec 21, 2019·Indian Journal of Ophthalmology·Daren HanumunthaduJay Chhablani
Feb 6, 2020·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Erica L Fletcher
Jul 16, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Liran TiosanoSrinivas R Sadda
Jul 31, 2019·Scientific Reports·Sajib SahaZhihong Jewel Hu
Feb 5, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Giulia CorradettiDavid Sarraf
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Mar 7, 2021·Journal of Clinical Medicine·Jackson ScharfDavid Sarraf
Mar 13, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mahima JhinganJay Chhablani
Mar 20, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cláudia FarinhaRufino Silva
Apr 14, 2021·Human Mutation·Marco NassisiIsabelle Audo
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Sep 13, 2021·American Journal of Ophthalmology·Philip J RosenfeldRuikang K Wang

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