Quantum dot-based theranostics.

Nanoscale
Yi-Ping Ho, Kam W Leong

Abstract

Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on developing new biosensing formats to push the limit of detection sensitivity. Nevertheless, QDs can be more than passive bio-probes or labels for biological imaging and cellular studies. The high surface-to-volume ratio of QDs enables the construction of a "smart" multifunctional nanoplatform, where the QDs serve not only as an imaging agent but also a nanoscaffold catering for therapeutic and diagnostic (theranostic) modalities. This mini review highlights the emerging applications of functionalized QDs as fluorescence contrast agents for imaging or as nanoscale vehicles for delivery of therapeutics, with special attention paid to the promise and challenges towards QD-based theranostics.

References

May 14, 1993·Science·R C Mulligan
Sep 25, 1998·Science·M BruchezA P Alivisatos
Nov 6, 1998·Pharmacology & Therapeutics·P D Robbins, S C Ghivizzani
Jun 15, 1996·Physical Review. B, Condensed Matter·D J Norris, M G Bawendi
Sep 14, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·S SomiariR W Malone
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·T Kirchhausen
Jul 19, 2002·Chemical Communications : Chem Comm·Joshua B EdelAndrew J deMello
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maria E AkermanErkki Ruoslahti
Dec 3, 2002·Science·Benoit DubertretAlbert Libchaber
Sep 13, 2003·Nature Materials·Aliasger K SalemKam W Leong
Oct 29, 2003·Current Opinion in Chemical Biology·Sharron G PennMichael J Natan
Jan 6, 2004·Nature Biotechnology·Diane S LidkeThomas M Jovin
Mar 5, 2004·Journal of the American Chemical Society·Andreas JahnLaurie E Locascio
May 13, 2004·Journal of the American Chemical Society·Fabien PinaudShimon Weiss
Jul 20, 2004·Nature Biotechnology·Xiaohu GaoShuming Nie
Nov 13, 2004·Angewandte Chemie·Eugenii Katz, Itamar Willner
Feb 22, 2005·Current Opinion in Biotechnology·Xiaohu GaoShuming Nie
Apr 14, 2005·Nano Letters·J Wagner, J M Köhler
Jun 2, 2005·Nature Materials·Igor L MedintzHedi Mattoussi
Jun 24, 2005·Angewandte Chemie·Jamie H WarnerRichard D Tilley
Jul 12, 2005·Annual Review of Biomedical Engineering·A Paul AlivisatosCarolyn Larabell
Aug 11, 2005·Journal of the American Chemical Society·Dhruba J BharaliParas N Prasad
Dec 15, 2005·Nucleic Acids Research·Alice A ChenSangeeta N Bhatia
Dec 28, 2005·Nature Materials·Chun-Yang ZhangTza-Huei Wang
Feb 24, 2006·Biosensors & Bioelectronics·Ted C ChuAndrew D Ellington
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan
Apr 15, 2006·Science·Ben N G GiepmansRoger Y Tsien
May 16, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Charudharshini SrinivasanDiane J Burgess
Jun 2, 2006·Nature Materials·David Putnam
Jul 19, 2006·Angewandte Chemie·Gopakumar GopalakrishnanHorst Vogel
Nov 4, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi-Ping HoTza-Huei Wang
Nov 7, 2006·Angewandte Chemie·Helen SongRustem F Ismagilov
Nov 10, 2006·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Dec 22, 2006·IEEE Transactions on Nanobioscience·Noriyoshi ManabeKenji Yamamoto
Dec 29, 2006·Small·Emmanuel ChangRebekah Drezek
Mar 24, 2007·Annual Review of Biochemistry·Stefan Wennmalm, Sanford M Simon
Jul 17, 2007·Bioconjugate Chemistry·Austin M DerfusSangeeta N Bhatia
Aug 21, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Meike L SchipperSanjiv S Gambhir
Sep 12, 2007·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Akiyoshi HoshinoKenji Yamamoto

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Citations

Jun 5, 2013·Analytical and Bioanalytical Chemistry·Kelly Boeneman GemmillIgor L Medintz
May 30, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hao HongWeibo Cai
Feb 6, 2013·Bioconjugate Chemistry·Kelly Boeneman GemmillIgor L Medintz
Oct 7, 2011·Molecular Pharmaceutics·Ruth Duncan, Rogerio Gaspar
Feb 23, 2013·International Journal of Nanomedicine·Leona DamalakieneRicardas Rotomskis
Aug 17, 2012·Theranostics·Koichi Baba, Kohji Nishida
Jan 15, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Sylwia Łukasiewicz, Krzysztof Szczepanowicz
Nov 30, 2011·AIP Advances·R D BoehmR J Narayan
Apr 5, 2012·Nanomedicine·Christopher L GrigsbyKam W Leong
Mar 28, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Bing XueYue-Qing Gu
Jul 25, 2012·Nanoscale·Georgiana StoicaEmilio Palomares
May 4, 2013·Expert Review of Molecular Diagnostics·Birgitta R KnudsenYi-Ping Ho
Jul 16, 2015·Journal of Drug Targeting·Mohammad Johari-AharMohammad-Reza Rashidi
Aug 18, 2012·Expert Opinion on Drug Delivery·Priti P PednekarVilasrao J Kadam
Apr 24, 2013·Critical Reviews in Biotechnology·Minhaz Uddin AhmedApril S Brown
Jun 26, 2012·Advanced Drug Delivery Reviews·Simona Mura, Patrick Couvreur
Dec 1, 2010·Nano Today·Gang LiuXiaoyuan Chen
Sep 23, 2010·Advanced Drug Delivery Reviews·Prakash RaiTayyaba Hasan
Aug 4, 2010·Biosensors & Bioelectronics·Arben Merkoçi
Jul 12, 2014·ACS Applied Materials & Interfaces·Brian T Luk, Liangfang Zhang
Jun 30, 2015·Advanced Healthcare Materials·Sue Hyun LeeJae Won Yang
Feb 25, 2015·Scientific Reports·Md Wasi AhmadGang Ho Lee
May 28, 2015·Scientific Reports·Haizhen ZhangYu-qiang Ma
Apr 5, 2013·Advanced Materials·Nohyun LeeTaeghwan Hyeon
Sep 11, 2010·Microscopy Research and Technique·Eliza Hutter, Dusica Maysinger
Jul 22, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Dan BaiNikolai V Tkachenko
Mar 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Changsuk LeeEric E Simanek
Aug 27, 2014·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Joyce BregerIgor L Medintz
Aug 28, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Estefania Gonzalez Solveyra, Igal Szleifer

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