PMID: 21462720Jan 1, 2010Paper

Quantum dots enhance Cu2+ -induced hepatic L02 cells toxicity

Journal of Environmental Sciences (China)
Yuxia ZhaoLili Liu

Abstract

As a new class of xenogenous nanoparticle, quantum dots (QDs) possess the potential to co-exist with CU2+ in human liver. The combined toxicity is thus concerned. Considering QDs and Cu2+ are known ROS (reactive oxygen species) inducer, we investigated the combined oxidative stress and corresponding protective strategy using human hepatic L02 cells. The results demonstrated that the presence of a small amount of MPA-CdTe QDs (2 microg/mL) in a Cu2+ solution (2.5-20 microg/mL) resulted in a higher toxicity with up to 8-fold cell viability decrease, which was accompanied by cell morphology changes. The combined toxicity was then confirmed as ROS associated oxidative stress with up to 300% and 35% increase of the intracellular ROS level and glutathione S-transferase (GST) activity, respectively. N-acetylcysteine (NAC) can also provide almost complete protection against the induced toxicity. Therefore, the ROS associated oxidant injury might be responsible for the QDs-Cu2+/CU2+ induced toxicity and could be balanced through cytoprotective antioxidant enzyme GST.

Citations

Jul 18, 2012·Journal of Materials Science. Materials in Medicine·Yang LuoMing Su
Apr 17, 2013·Journal of Environmental Sciences (China)·Kavitha PathakotiAndrew Wang
Dec 29, 2015·Biotechnology Journal·Abhishek MukherjeeJoon Myong Song
Feb 21, 2013·Environmental Pollution·Wei ZhangChangjiang Huang
May 31, 2012·Drug Delivery·Ravikumar AalinkeelStanley A Schwartz
Mar 18, 2015·Chemical Society Reviews·K David Wegner, Niko Hildebrandt
Jan 1, 2019·Journal of Biochemical and Molecular Toxicology·Morihiko Nakamura, Natsuko Watanabe

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