Quartz crystal microbalance for the determination of daminozide using molecularly imprinted polymers as recognition element

Biosensors & Bioelectronics
Shoulei YanZhixian Gao

Abstract

As the daminozide (DM) and its metabolite have been identified to be potentially carcinogenic, rapid detection method for them is necessary for food safety. A type of piezoelectric crystal sensor has been prepared by using a molecularly imprinted polymer (MIP) as recognition element. The molecularly imprinted polymer was prepared by hot-induced precipitation polymerization, and then the polymer particles were fixed on the surface of the electrode. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were employed to evaluate the obtained imprinted polymer particles and the MIP sensitive film coated on the electrode. The results showed that a typical time-response curve of the MIP-coated crystal to the DM solution had been given, frequency shifts versus logarithm changes of DM showed good linear correlation within the concentration range of 1.0x10(-9) to 10(-6) mg/mL (y=11.38 lg x+115.45, r=0.9872) and 1.0x10(-6) to 10(-1) mg/mL (y=25.22lgx+209.44, r=0.9938), respectively. The detection limit was 5.0x10(-8) mg/mL (S/N=3), which is lower than that of conventional methods. Further, computer simulation technology was employed to investigate the interaction between methacrylic acid and DM for elucidating the recognit...Continue Reading

References

May 24, 2001·Fresenius' Journal of Analytical Chemistry·M MinunniM Mascini
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Nov 24, 2004·Biosensors & Bioelectronics·Franz L DickertChristian Palfinger
Nov 24, 2004·Biosensors & Bioelectronics·Olena SlinchenkoNorihiko Minoura
Oct 31, 2008·Talanta·I NavrátilováV Viklický

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Citations

Oct 22, 2011·International Journal of Molecular Sciences·Giuseppe VasapolloGiuseppe Mele
Aug 4, 2011·Journal of Molecular Recognition : JMR·Bernd Becker, Matthew A Cooper
Apr 5, 2014·Journal of Molecular Recognition : JMR·Michael J WhitcombeIan A Nicholls
Jan 16, 2008·Journal of Separation Science·Wei YaoZhixian Gao
Dec 27, 2016·Journal of Analytical Methods in Chemistry·Rachel Marcella Roland, Showkat Ahmad Bhawani
Dec 13, 2018·Journal of Chemical Theory and Computation·Francesca NerattiniIvan Coluzza
Jan 24, 2008·Chemical Reviews·Radislav A Potyrailo, Vladimir M Mirsky

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