Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disorders.

International Journal of Molecular Sciences
Hideya AndoMasamitsu Ichihashi

Abstract

Excess production of melanin or its abnormal distribution, or both, can cause irregular hyperpigmentation of the skin, leading to melasma and age spots. To date, various quasi-drugs that prevent or improve hyperpigmentary disorders have been developed and officially approved by the Ministry of Health, Labor and Welfare of Japan. Many of these inhibit the activity of tyrosinase, an enzyme required for melanin synthesis, for example, by competitive or non-competitive inhibition of its catalytic activity, by inhibiting its maturation, or by accelerating its degradation. In this review, we categorize the quasi-drugs developed in Japan to prevent or treat hyperpigmentary disorders, or both, and discuss perspectives for future development.

References

Jan 1, 1996·Journal of the American Academy of Dermatology·K KameyamaK Blanock
Sep 28, 1998·Archives of Dermatological Research·H AndoM Ichihashi
Apr 5, 2001·The Journal of Investigative Dermatology·C PaineM Seiberg
Sep 14, 2001·International Journal of Dermatology·S M JavaheriB Kumar
Jul 9, 2002·The British Journal of Dermatology·T HakozakiR E Boissy
Dec 18, 2002·The Journal of Investigative Dermatology·C B LinM Seiberg
Mar 8, 2003·Pigment Cell Research·Stefania BrigantiMauro Picardo
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tamotsu TakizawaMasao Hirose
Sep 3, 2003·Pigment Cell Research·Kyoko NakamuraMasako Mizoguchi
Mar 11, 2004·The Journal of Investigative Dermatology·Kazuhisa Maeda, Masato Hatao
Apr 2, 2004·Biological & Pharmaceutical Bulletin·Yasutami ShigetaTaketoshi Makino
Apr 22, 2004·Journal of Thrombosis and Haemostasis : JTH·N WangJ Hoover-Plow
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Mar 15, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Khalifa E SharquieSabeeh A Al-Mashhadani
Dec 6, 2005·Biological & Pharmaceutical Bulletin·Dong-Seok KimKyoung-Chan Park
Jan 20, 2006·Pigment Cell Research·Ning Wang, Daniel N Hebert
Feb 16, 2006·Biochimica Et Biophysica Acta·Yuko ItoAkihiro Tada
Nov 7, 2006·Pigment Cell Research·Francisco SolanoGhanem Ghanem
Dec 15, 2006·Journal of Cosmetic Dermatology·W Westerhof, T J Kooyers
Jan 16, 2007·The Journal of Investigative Dermatology·Hideya AndoVincent J Hearing
Jun 1, 2007·The Journal of Toxicological Sciences·Yoshitaka HigaMichihito Takahashi
May 28, 2008·International Journal of Cosmetic Science·H ShimogakiM Masuda

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Citations

Nov 2, 2013·Indian Journal of Dermatology, Venereology and Leprology·Munisamy Malathi, Devinder M Thappa
Jul 22, 2014·International Journal of Molecular Sciences·Seung-Hwa BaekSang-Han Lee
Oct 23, 2014·The Journal of Investigative Dermatology·Mary S MatsuiDaniel B Yarosh
Jul 22, 2014·International Journal of Dermatology·Yoichi FukushimaKazuo Kondo
Oct 9, 2015·Oxidative Medicine and Cellular Longevity·Saima JadoonGhulam Murtaza
Oct 11, 2011·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Virendra N SehgalSangeeta Verma
Dec 29, 2019·Journal of Biochemistry·Toshiyuki HommaKozo Nagata
Mar 18, 2015·Experimental Dermatology·Motoki NakamuraJean Krutmann
May 23, 2021·Journal of Cosmetic Dermatology·Rabia TasneemPalwasha Khan

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Methods Mentioned

BETA
glycosylation

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