Quasi-Static Optical Coherence Elastography to Characterize Human Corneal Biomechanical Properties

Investigative Ophthalmology & Visual Science
Sabine KlingFarhad Hafezi

Abstract

Quasi-static optical coherence elastography (OCE) is an emerging technology to investigate corneal biomechanical behavior in situations similar to physiological stress conditions. Herein OCE was applied to evaluate previously inaccessible biomechanical characteristics of human corneal tissue and to study the role of Bowman's layer in corneal biomechanics. Human corneal donor buttons (n = 23) were obtained and Descemet's membrane and endothelium were removed. In 11 corneas, Bowman's layer was ablated by a 20 µm stromal excimer laser ablation. Buttons were mounted on an artificial anterior chamber and subjected to a pressure modulation from 10 to 30 mm Hg, and back to 10 mm Hg, in steps of 1 mm Hg. At each step, a spectral-domain optical coherence tomography scan was obtained. Displacements were analyzed by optical flow tracking, and strain over the entire stromal depth was retrieved from the phase gradient of the complex interference signal. During pressure increase, corneal tissue moved upward (486-585 nm/mm Hg) but did not fully recover (Δ= 2.63 to 8.64 µm) after pressure decrease. Vertical corneal strain distribution was negative in the anterior and positive in the posterior cornea, indicating simultaneous corneal compression...Continue Reading

References

May 1, 1992·The British Journal of Ophthalmology·R DavidY Yassur
May 1, 1992·Journal of Biomechanical Engineering·D A HoeltzelK Choe
Jul 1, 1996·Journal of Biomechanics·J O Hjortdal
Mar 27, 2001·Journal of Biomechanics·Y ZengX Lee
Oct 3, 2003·Journal of Cataract and Refractive Surgery·Gregor WollensakTheo Seiler
Jul 20, 2006·Journal of the Royal Society, Interface·Ahmed Elsheikh, Kevin Anderson
Apr 9, 2008·Experimental Eye Research·Ahmed ElsheikhPaolo Rama
Jul 8, 2008·Biomaterials·Brad L BoyceThao D Nguyen
Mar 26, 2010·Investigative Ophthalmology & Visual Science·Sabine KlingSusana Marcos
Sep 18, 2010·Investigative Ophthalmology & Visual Science·Nathaniel E Knox CartwrightJohn Marshall
Apr 5, 2011·Investigative Ophthalmology & Visual Science·Aizhu TaoMohamed Abou Shousha
Dec 14, 2011·Investigative Ophthalmology & Visual Science·Giuliano ScarcelliSeok Hyun Yun
Mar 17, 2012·Micron : the International Research and Review Journal for Microscopy·Julie A LastChristopher J Murphy
Jun 19, 2014·Investigative Ophthalmology & Visual Science·Giuliano ScarcelliSeok Hyun Yun
Mar 22, 2015·The British Journal of Ophthalmology·Anastasios John KanellopoulosJoseph B Ciolino
Jul 12, 2016·Journal of Refractive Surgery·Jaakko S Mattila, Juha M Holopainen
Dec 9, 2016·Journal of Refractive Surgery·Riccardo VinciguerraPaolo Vinciguerra
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Peng ShaoSeok-Hyun Yun
Feb 18, 2019·American Journal of Ophthalmology·Theo G SeilerSeok-Hyun Yun

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Citations

Dec 15, 2020·Journal of Cataract and Refractive Surgery·Emilio A Torres-NettoSabine Kling
Jul 31, 2021·Translational Vision Science & Technology·Brecken J BlackburnWilliam J Dupps
Dec 17, 2021·Journal of Refractive Surgery·Bogdan SpiruWalter Sekundo

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atomic force measurements

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