Quaternary ammonium chitosan derivative dynamic coating for the separation of veterinary sulfonamide residues by CE with field-amplified sample injection

Electrophoresis
Ming MaHong Wang

Abstract

A quaternary ammonium chitosan, 2-hydroxypropyltrimethylammonium chloride chitosan (HACC), has been developed for the dynamic coating material in CE for the first time. It presented many advantages such as favorable water solubility, satisfactory coating efficiency, and EOF toward the anode at pH >7.0. Using the modified fused-silica capillary, sulfonamides (SAs), an important group of veterinary drugs, were separated and detected by CE combined with field-amplified sample injection (FASI). The LODs of sulfonamides with UV detection were less than 0.5 ng/mL. The proposed method has been applied to the determination of veterinary sulfonamide residues in samples such as chicken, beef, and honey with fast separation (15 sulfonamides within 20 min), low LODs (0.1-0.5 ng/mL), and good reliability compared to the criteria of China (GB/T 18932.17-2003).

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Citations

Jun 18, 2009·Analytical and Bioanalytical Chemistry·Ana M García-CampañaCarmen Cruces-Blanco
Oct 31, 2009·Journal of Separation Science·María Asensio-RamosSalvatore Fanali
Feb 18, 2010·Electrophoresis·Stefan BachmannGünther K Bonn
Jun 28, 2015·International Journal of Biological Macromolecules·Riham R MohamedMagdy W Sabaa
Jan 27, 2010·Analytical and Bioanalytical Chemistry·Siu-kay WongChi-ho Lam

Related Concepts

Quaternary Ammonium Compounds
Sulfonamides
Electrophoresis, Capillary
Veterinary Drugs
Chitosan

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