Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4.

Journal of Virology
J E RobinsonLeonidas Stamatatos

Abstract

Monoclonal antibodies (MAbs) that neutralize human immunodeficiency virus type 1 (HIV-1) have been isolated from HIV-1-infected individuals or animals immunized with recombinant HIV-1 envelope (Env) glycoprotein constructs. The epitopes of these neutralizing antibodies (NAbs) were shown to be located on either the variable or conserved regions of the HIV-1 Env and to be linear or conformational. However, one neutralizing MAb, 2909, which was isolated from an HIV-1-infected subject, recognizes a more complex, quaternary epitope that is present on the virion-associated functional trimeric Env spike of the SF162 HIV-1 isolate. Here, we discuss the isolation of 11 anti-HIV NAbs that were isolated from three rhesus macaques infected with the simian/human immunodeficiency virus SHIV(SF162P4) and that also recognize quaternary epitopes. A detailed epitope mapping analysis of three of these rhesus antibodies revealed that their epitopes overlap that of the human MAb 2909. Despite this overall similarity in binding, however, differences in specific amino acid and glycosylation pattern requirements for MAb 2909 and the rhesus MAbs were identified. These results highlight similarities in the B-cell responses of humans and macaques to stru...Continue Reading

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Citations

Jun 26, 2010·Nature Reviews. Immunology·Susan Zolla-Pazner, Timothy Cardozo
Dec 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Li LiuEdward A Berger
Oct 6, 2012·AIDS Research and Human Retroviruses·Nicos KarasavvasUNKNOWN MOPH TAVEG Collaboration
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Peter D KwongGary J Nabel
Jan 21, 2011·PLoS Pathogens·Iliyana MikellLeonidas Stamatatos
Sep 18, 2013·Journal of Immunological Methods·Carsten MagnusRoland R Regoes
Sep 18, 2013·Journal of Immunological Methods·Christian GaeblerFlorian Klein
May 19, 2012·Current Opinion in Immunology·Leonidas Stamatatos
Sep 20, 2012·Journal of Immunological Methods·Christopher SundlingGunilla B Karlsson Hedestam
May 29, 2015·Journal of Virology·Ruimin PanXiang-Peng Kong
Nov 28, 2018·Retrovirology·Jelle van Schooten, Marit J van Gils
Apr 27, 2017·Cell Reports·Tongqing ZhouPeter D Kwong
Jun 25, 2021·Frontiers in Molecular Biosciences·Nathaniel L MillerRam Sasisekharan

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