Quaternary structure of the liver microsomal cytochrome P-450

FEBS Letters
V L TsuprunV P Skulachev

Abstract

Cytochrome P-450LM2 was isolated from rabbit liver microsomes in a form which was shown to be homogeneous in AcA-22 Ultrogel and ultracentrifugation studies. The molecular mass determined by sedimentation equilibrium roughly corresponded to hexamer composed of 56 kDa monomers. Hexamer structure of the cytochrome was directly demonstrated by electron microscopic study. In the cytochrome P-450LM2 hexamer, monomers seem to be arranged in two layers (three monomers in the layer) in such a way that each monomer occupies a position at the vertices of a triangular antiprism with a 32 point group symmetry.

References

Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G E TarrM J Coon
Sep 30, 1982·Biochemical and Biophysical Research Communications·L S Baskin, C S Yang

❮ Previous
Next ❯

Citations

Jan 1, 1990·Electron Microscopy Reviews·N A KiselevV L Tsuprun
Nov 25, 2003·Biochemical and Biophysical Research Communications·Dmitri R DavydovGaston Hui Bon Hoa
May 3, 2003·Pharmacology & Therapeutics·Wayne L Backes, Rusty W Kelley
Mar 11, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Murali SubramanianTimothy S Tracy
Nov 4, 2008·Biochemistry. Biokhimii︠a︡·K N Myasoedova
Aug 3, 2010·Biochemistry. Biokhimii︠a︡·K N Myasoedova, K N Timofeev
Oct 16, 2007·Doklady. Biochemistry and Biophysics·K N MyasoedovaN N Magretova
Oct 12, 2000·Biochemical and Biophysical Research Communications·D R DavydovG H Hoa
Dec 14, 2011·Pharmacology & Therapeutics·James R Reed, Wayne L Backes
Jun 29, 2012·The Biochemical Journal·James R ReedWayne L Backes
Mar 15, 2011·Expert Opinion on Drug Metabolism & Toxicology·Dmitri R Davydov
Jun 17, 2006·Bioscience Reports·Ksenia N MyasoedovaNatalya N Magretova
Nov 26, 1990·FEBS Letters·K N Myasoedova, P Berndt
Sep 17, 1990·FEBS Letters·K N Myasoedova, P Berndt
May 16, 2015·Biomedit︠s︡inskai︠a︡ khimii︠a︡·D R Davydov
Jul 5, 1993·FEBS Letters·K N Myasoedova, V L Tsuprun
Nov 4, 1998·Archives of Biochemistry and Biophysics·M L Shank-RetzlaffS G Sligar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.